RsmY RNA family
| RsmY RNA family | |
|---|---|
 Predicted secondary structure and sequence conservation of RsmY | |
| Identifiers | |
| Symbol | RsmY |
| Rfam | RF00195 |
| Other data | |
| RNA type | Gene; sRNA |
| Domain(s) | Bacteria |
| SO | SO:0000655 |
| PDB structures | PDBe |
The rsmY RNA family is a set of related non-coding RNA genes, that like RsmZ, is regulated by the GacS/GacA signal transduction system in the plant-beneficial soil bacterium and biocontrol model organism Pseudomonas fluorescens CHA0. GacA/GacS target genes are translationally repressed by the small RNA binding protein RsmA. RsmY and RsmZ RNAs bind to relieve this repression and so enhance secondary metabolism and biocontrol traits.[1]
Studies in Legionella pneumophila have shown that the ncRNAs RsmY and RsmZ together with the proteins and CsrA are involved in a regulatory cascade. Also, it appears that these ncRNAs are regulated by RpoS sigma-factor.[2]
See also[]
References[]
- ^ Valverde C, Heeb S, Keel C, Haas D (November 2003). "RsmY, a small regulatory RNA, is required in concert with RsmZ for GacA-dependent expression of biocontrol traits in Pseudomonas fluorescens CHA0". Molecular Microbiology. 50 (4): 1361–1379. doi:10.1046/j.1365-2958.2003.03774.x. PMID 14622422.
- ^ Rasis M, Segal G (May 2009). "The LetA-RsmYZ-CsrA regulatory cascade, together with RpoS and PmrA, post-transcriptionally regulates stationary phase activation of Legionella pneumophila Icm/Dot effectors". Molecular Microbiology. 72 (4): 995–1010. doi:10.1111/j.1365-2958.2009.06705.x. PMID 19400807. S2CID 37262658.
Further reading[]
- Brencic A, McFarland KA, McManus HR, Castang S, Mogno I, Dove SL, Lory S (August 2009). "The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs". Molecular Microbiology. 73 (3): 434–445. doi:10.1111/j.1365-2958.2009.06782.x. PMC 2761719. PMID 19602144.
- Sorger-Domenigg T, Sonnleitner E, Kaberdin VR, Bläsi U (January 2007). "Distinct and overlapping binding sites of Pseudomonas aeruginosa Hfq and RsmA proteins on the non-coding RNA RsmY". Biochemical and Biophysical Research Communications. 352 (3): 769–773. doi:10.1016/j.bbrc.2006.11.084. PMID 17141182.
- Valverde C, Lindell M, Wagner EG, Haas D (June 2004). "A repeated GGA motif is critical for the activity and stability of the riboregulator RsmY of Pseudomonas fluorescens". The Journal of Biological Chemistry. 279 (24): 25066–25074. doi:10.1074/jbc.M401870200. PMID 15031281.
External links[]
- Page for RsmY RNA family at Rfam
- Pfam page for the CsrA protein family[permanent dead link]
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- Non-coding RNA
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