SAFB2

SAFB2
Identifiers
Aliases	SAFB2, scaffold attachment factor B2
External IDs	OMIM: 608066 MGI: 2146808 HomoloGene: 35210 GeneCards: SAFB2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	5,624,046 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	56,584,585 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; cerebellar hemisphere; ; anterior pituitary;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleic acid binding; identical protein binding; GO:0001948 protein binding; double-stranded DNA binding; RNA binding; sequence-specific DNA binding;
Cellular component	extracellular exosome; nucleoplasm; cytoplasm; intracellular membrane-bounded organelle; nucleus; nuclear body;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; Sertoli cell differentiation; regulation of transcription by RNA polymerase II; regulation of androgen receptor signaling pathway; regulation of mRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	9667
	224902
	ENSG00000130254
	ENSMUSG00000042625
	Q14151
	Q80YR5
	NM_014649
	NM_001029979; NM_001355463
	NP_055464
	NP_001025150; NP_001342392
	Wikidata
View/Edit Human	View/Edit Mouse

Scaffold attachment factor B2 is a protein that in humans is encoded by the SAFB2 gene.^[5]^[6]

Interactions[]

SAFB2 has been shown to interact with Estrogen receptor alpha^[5] and SAFB.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130254 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042625 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Townson SM, Dobrzycka KM, Lee AV, Air M, Deng W, Kang K, Jiang S, Kioka N, Michaelis K, Oesterreich S (May 2003). "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor". J. Biol. Chem. 278 (22): 20059–68. doi:10.1074/jbc.M212988200. PMID 12660241.
^ "Entrez Gene: SAFB2 scaffold attachment factor B2".

Oesterreich S (2003). "Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?". J. Cell. Biochem. 90 (4): 653–61. doi:10.1002/jcb.10685. PMID 14587024. S2CID 39178501.
Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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