SEC23IP

SEC23IP
Identifiers
Aliases	SEC23IP, P125, P125A, MSTP053, SEC23 interacting protein, iPLA1beta
External IDs	OMIM: 617852 MGI: 2450915 HomoloGene: 38288 GeneCards: SEC23IP
Gene location (Human)
Chr.	Chromosome 10 (human)
End	119,944,657 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	128,386,560 bp
RNA expression pattern
	Top expressed in
	stomach; ; lung; ; heart; ; Achilles tendon; ; islet of Langerhans; ; smooth muscle tissue; ; ovary; ; colon;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GO:0001948 protein binding; metal ion binding; phospholipase activity; RNA binding;
Cellular component	cytoplasm; ER to Golgi transport vesicle membrane; cytosol; endoplasmic reticulum; membrane; GO:0016023 cytoplasmic vesicle; endoplasmic reticulum-Golgi intermediate compartment; Golgi membrane; COPII-coated ER to Golgi transport vesicle; Golgi apparatus; intracellular membrane-bounded organelle;
Biological process	COPII vesicle coating; intracellular protein transport; Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport;
	Sources:Amigo / QuickGO
Orthologs
	11196
	207352
	ENSG00000107651
	ENSMUSG00000055319
	Q9Y6Y8
	Q6NZC7
	NM_007190
	NM_001029982
	NP_009121
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.^[5]^[6]

COPII-coated vesicles are involved in protein transport from the Endoplasmic Reticulum to the Golgi Apparatus. The protein encoded by this gene was identified by its interaction with a mouse protein similar to yeast Sec23p, an essential component of the COPII. This protein shares significant similarity with phospholipid-modifying proteins, especially phosphatidic acid preferring-phospholipase A1. Overexpression of this protein has been shown to cause disorganization of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus, which suggests its role in the early secretory pathway.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107651 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000055319 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M (Aug 1999). "p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins". J Biol Chem. 274 (29): 20505–12. doi:10.1074/jbc.274.29.20505. PMID 10400679.
^ ^a ^b "Entrez Gene: SEC23IP SEC23 interacting protein".

Further reading[]

Li H, Xie B, Zhou Y, et al. (2006). "Functional roles of p12, the fourth subunit of human DNA polymerase delta". J. Biol. Chem. 281 (21): 14748–55. doi:10.1074/jbc.M600322200. PMID 16510448.
Shimoi W, Ezawa I, Nakamoto K, et al. (2005). "p125 is localized in endoplasmic reticulum exit sites and involved in their organization". J. Biol. Chem. 280 (11): 10141–8. doi:10.1074/jbc.M409673200. PMID 15623529.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mizoguchi T, Nakajima K, Hatsuzawa K, et al. (2001). "Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein". Biochem. Biophys. Res. Commun. 279 (1): 144–9. doi:10.1006/bbrc.2000.3846. PMID 11112430.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107651 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055319 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10400679-5] Tani K, Mizoguchi T, Iwamatsu A, Hatsuzawa K, Tagaya M (Aug 1999). "p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins". J Biol Chem. 274 (29): 20505–12. doi:10.1074/jbc.274.29.20505. PMID 10400679.

[entrez-6] "Entrez Gene: SEC23IP SEC23 interacting protein".

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