SEMA5A

SEMA5A
Identifiers
Aliases	SEMA5A, SEMAF, semF, semaphorin 5A
External IDs	OMIM: 609297 MGI: 107556 HomoloGene: 2949 GeneCards: SEMA5A
Gene location (Human)
Chr.	Chromosome 5 (human)
End	9,546,075 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	32,696,487 bp
RNA expression pattern
	Top expressed in
	metanephric glomerulus; ; glomerulus; ; heart; ; female reproductive system; ; periodontal fiber; ; colon; ; trigeminal ganglion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chondroitin sulfate proteoglycan binding; heparan sulfate proteoglycan binding; syndecan binding; semaphorin receptor binding; neuropilin binding; chemorepellent activity;
Cellular component	membrane; plasma membrane; extracellular exosome; integral component of membrane; extracellular space;
Biological process	negative regulation of endothelial cell apoptotic process; negative regulation of cell adhesion; cell differentiation; positive regulation of protein kinase B signaling; positive regulation of endothelial cell proliferation; positive regulation of endothelial cell chemotaxis; cell-cell signaling; positive regulation of axon extension involved in axon guidance; blood vessel endothelial cell proliferation involved in sprouting angiogenesis; nervous system development; positive regulation of angiogenesis; multicellular organism development; diencephalon development; cell adhesion; signal clustering; cell chemotaxis; positive chemotaxis; axonal fasciculation; positive regulation of actin filament depolymerization; negative regulation of axon extension involved in axon guidance; negative chemotaxis; neural crest cell migration; positive regulation of cell migration; semaphorin-plexin signaling pathway; positive regulation of canonical Wnt signaling pathway; axon extension; neuron projection guidance;
	Sources:Amigo / QuickGO
Orthologs
	9037
	20356
	ENSG00000112902
	ENSMUSG00000022231
	Q13591
	Q62217; Q3UPZ0
	NM_003966
	NM_009154
	NP_003957
	NP_033180
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.^[5]^[6]^[7]

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM]^[7]

Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016).

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112902 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022231 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev. 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451. S2CID 17827262.
^ Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
^ ^a ^b "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".

Further reading[]

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Simmons AD, Overhauser J, Lovett M (1997). "Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library". Genome Res. 7 (2): 118–27. doi:10.1101/gr.7.2.118. PMID 9049630.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Artigiani S, Conrotto P, Fazzari P, et al. (2005). "Plexin-B3 is a functional receptor for semaphorin 5A". EMBO Rep. 5 (7): 710–4. doi:10.1038/sj.embor.7400189. PMC 1299100. PMID 15218527.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. Bibcode:2004Natur.431..268S. doi:10.1038/nature02919. PMID 15372022.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Melin M, Carlsson B, Anckarsater H, et al. (2007). "Constitutional downregulation of SEMA5A expression in autism". Neuropsychobiology. 54 (1): 64–9. doi:10.1159/000096040. PMC 2553518. PMID 17028446.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112902 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022231 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8817451-5] Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev. 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451. S2CID 17827262.

[pmid9464278-6] Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.

[entrez-7] "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".

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