SH2 domain-containing protein 1B is a protein that in humans is encoded by the SH2D1Bgene.[5][6][7]
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001).[supplied by OMIM][7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Thompson AD, Braun BS, Arvand A, Stewart SD, May WA, Chen E, Korenberg J, Denny C (Feb 1997). "EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene". Oncogene. 13 (12): 2649–58. PMID9000139.
Morra M, Howie D, Grande MS, et al. (2001). "X-linked lymphoproliferative disease: a progressive immunodeficiency". Annu. Rev. Immunol. 19: 657–82. doi:10.1146/annurev.immunol.19.1.657. PMID11244050.
Veillette A, Latour S (2004). "The SLAM family of immune-cell receptors". Curr. Opin. Immunol. 15 (3): 277–85. doi:10.1016/S0952-7915(03)00041-4. PMID12787752.