SH3BP5

SH3BP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H3B
Identifiers
Aliases	SH3BP5, SAB, SH3BP-5, SH3 domain binding protein 5
External IDs	OMIM: 605612 MGI: 1344391 HomoloGene: 23450 GeneCards: SH3BP5
Gene location (Human)
Chr.	Chromosome 3 (human)
End	15,341,368 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	31,158,035 bp
RNA expression pattern
	Top expressed in
	adrenal cortex; ; adrenal gland; ; upper lobe of lung; ; visceral pleura; ; ovary; ; myometrium;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; GO:0001948 protein binding; SH3 domain binding; guanyl-nucleotide exchange factor activity;
Cellular component	cytoplasm; mitochondrion; nucleoplasm; nuclear body; cytoplasmic vesicle membrane; membrane; GO:0016023 cytoplasmic vesicle;
Biological process	signal transduction; negative regulation of protein tyrosine kinase activity; GO:0007243 intracellular signal transduction; negative regulation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	9467
	24056
	ENSG00000131370
	ENSMUSG00000021892
	O60239
	Q9Z131
	NM_001018009; NM_004844
	NM_011894; NM_001347585
	NP_001018009; NP_004835
	NP_001334514; NP_036024
	Wikidata
View/Edit Human	View/Edit Mouse

SH3 domain-binding protein 5 is a protein that in humans is encoded by the SH3BP5 gene.^[5]^[6]^[7]

Interactions[]

SH3BP5 has been shown to interact with Bruton's tyrosine kinase^[5]^[6] and MAPK8.^[8]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131370 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021892 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Matsushita M; Yamadori T; Kato S; Takemoto Y; Inazawa J; Baba Y; Hashimoto S; Sekine S; Arai S; Kunikata T; Kurimoto M; Kishimoto T; Tsukada S (June 1998). "Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)". Biochem Biophys Res Commun. 245 (2): 337–43. doi:10.1006/bbrc.1998.8420. PMID 9571151.
^ ^a ^b Yamadori T; Baba Y; Matsushita M; Hashimoto S; Kurosaki M; Kurosaki T; Kishimoto T; Tsukada S (June 1999). "Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein". Proc Natl Acad Sci U S A. 96 (11): 6341–6. Bibcode:1999PNAS...96.6341Y. doi:10.1073/pnas.96.11.6341. PMC 26883. PMID 10339589.
^ "Entrez Gene: SH3BP5 SH3-domain binding protein 5 (BTK-associated)".
^ Wiltshire, Carolyn; Matsushita Masato; Tsukada Satoshi; Gillespie David A F; May Gerhard H W (November 2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". Biochem. J. England. 367 (Pt 3): 577–85. doi:10.1042/BJ20020553. ISSN 0264-6021. PMC 1222945. PMID 12167088.

Further reading[]

Baba Y, Matsushita M, Matsuda Y, et al. (2000). "Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding protein which preferentially associates with Bruton's tyrosine kinase, to human chromosome 1q43 and mouse chromosome 14B by in situ hybridization". Cytogenet. Cell Genet. 87 (3–4): 221–2. doi:10.1159/000015430. PMID 10702676. S2CID 41425074.
Wiltshire C, Matsushita M, Tsukada S, et al. (2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". Biochem. J. 367 (Pt 3): 577–85. doi:10.1042/BJ20020553. PMC 1222945. PMID 12167088.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Court NW; Kuo I; Quigley O; Bogoyevitch MA (2004). "Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3". Biochem. Biophys. Res. Commun. 319 (1): 130–7. doi:10.1016/j.bbrc.2004.04.148. PMID 15158451.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiltshire C; Gillespie DA; May GH (2005). "Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein". Biochem. Soc. Trans. 32 (Pt 6): 1075–7. doi:10.1042/BST0321075. PMID 15506969.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131370 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021892 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9571151-5] Matsushita M; Yamadori T; Kato S; Takemoto Y; Inazawa J; Baba Y; Hashimoto S; Sekine S; Arai S; Kunikata T; Kurimoto M; Kishimoto T; Tsukada S (June 1998). "Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)". Biochem Biophys Res Commun. 245 (2): 337–43. doi:10.1006/bbrc.1998.8420. PMID 9571151.

[pmid10339589-6] Yamadori T; Baba Y; Matsushita M; Hashimoto S; Kurosaki M; Kurosaki T; Kishimoto T; Tsukada S (June 1999). "Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein". Proc Natl Acad Sci U S A. 96 (11): 6341–6. Bibcode:1999PNAS...96.6341Y. doi:10.1073/pnas.96.11.6341. PMC 26883. PMID 10339589.

[entrez-7] "Entrez Gene: SH3BP5 SH3-domain binding protein 5 (BTK-associated)".

[pmid12167088-8] Wiltshire, Carolyn; Matsushita Masato; Tsukada Satoshi; Gillespie David A F; May Gerhard H W (November 2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". Biochem. J. England. 367 (Pt 3): 577–85. doi:10.1042/BJ20020553. ISSN 0264-6021. PMC 1222945. PMID 12167088.

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