SHCBP1

SHCBP1
Identifiers
Aliases	SHCBP1, PAL, SHC binding and spindle associated 1
External IDs	OMIM: 611027 MGI: 1338802 HomoloGene: 32123 GeneCards: SHCBP1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	46,621,379 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	4,829,567 bp
RNA expression pattern
	Top expressed in
	liver; ; bone marrow; ; thymus; ; appendix; ; testicle; ; cancellous bone; ; heart; ; sural nerve; ; lymph node;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH2 domain binding; GO:0001948 protein binding;
Cellular component	cytoskeleton; cytoplasm; spindle; midbody;
Biological process	regulation of neural precursor cell proliferation; fibroblast growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	79801
	20419
	ENSG00000171241
	ENSMUSG00000022322
	Q8NEM2
	Q9Z179
	NM_024745; NM_001324318; NM_001324319
	NM_011369
	NP_001311247; NP_001311248; NP_079021
	NP_035499
	Wikidata
View/Edit Human	View/Edit Mouse

SHC SH2 domain-binding protein 1 is a protein that in humans is encoded by the SHCBP1 gene.^[5]^[6]

Interactions[]

SHCBP1 has been shown to interact with SHC1.^[5]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171241 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022322 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Schmandt R, Liu SK, McGlade CJ (Mar 1999). "Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells". Oncogene. 18 (10): 1867–1879. doi:10.1038/sj.onc.1202507. PMID 10086341.
^ "Entrez Gene: SHCBP1 SHC SH2-domain binding protein 1".

Further reading[]

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–120. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–1450. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171241 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022322 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10086341-5] Schmandt R, Liu SK, McGlade CJ (Mar 1999). "Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells". Oncogene. 18 (10): 1867–1879. doi:10.1038/sj.onc.1202507. PMID 10086341.

[entrez-6] "Entrez Gene: SHCBP1 SHC SH2-domain binding protein 1".

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