SNAPC4

SNAPC4
Identifiers
Aliases	SNAPC4, PTFalpha, SNAP190, small nuclear RNA activating complex polypeptide 4
External IDs	OMIM: 602777 MGI: 2443935 HomoloGene: 2321 GeneCards: SNAPC4
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 136,375,567 bp[1] End 136,400,176 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 26,252,777 bp[2] End 26,270,665 bp[2]
RNA expression pattern Bgee Top expressed in vastus lateralis muscle Right lobe of liver cerebellar hemisphere testicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity DNA binding sequence-specific DNA binding GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm snRNA-activating protein complex Biological process regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated snRNA transcription by RNA polymerase III transcription by RNA polymerase III regulation of transcription by RNA polymerase II snRNA transcription by RNA polymerase II cell differentiation snRNA transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6621	227644
Ensembl	ENSG00000165684	ENSMUSG00000036281
UniProt	Q5SXM2	Q8BP86
RefSeq (mRNA)	NM_003086 NM_001394201 NM_001394202 NM_001394203	NM_001290419 NM_172339
RefSeq (protein)	NP_003077	NP_001277348 NP_758842
Location (UCSC)	Chr 9: 136.38 – 136.4 Mb	Chr 2: 26.25 – 26.27 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

snRNA-activating protein complex subunit 4 is a protein that in humans is encoded by the SNAPC4 gene.^[5][6]

Model organisms[]

Model organisms have been used in the study of SNAPC4 function. A conditional knockout mouse line, called Snapc4^{tm1a(KOMP)Wtsi[11][12]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.^[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[9][16] Twenty six tests were carried out on mutant mice and two significant abnormalities were observed. No homozygous mutant embryos were recorded during gestation and, in a separate study, no homozygous animals were observed at weaning. The remaining tests were carried out on adult heterozygous mutant animals and no further abnormalities were observed.^[9]

Interactions[]

SNAPC4 has been shown to interact with SNAPC1,^[17] POU2F1^[5][18] and SNAPC2.^[5][17]

References[]

Further reading[]