SOAT2

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SOAT2
Identifiers
AliasesSOAT2, ACACT2, ACAT2, ARGP2, sterol O-acyltransferase 2
External IDsOMIM: 601311 MGI: 1332226 HomoloGene: 68355 GeneCards: SOAT2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003578

NM_146064

RefSeq (protein)

NP_003569

NP_666176

Location (UCSC)Chr 12: 53.1 – 53.12 MbChr 15: 102.15 – 102.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme that in humans is encoded by the SOAT2 gene.[5]

Function[]

This gene is a member of a small family of Acyl-CoA:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very-low-density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.[5]

References[]

  1. ^ Jump up to: a b c GRCh38: Ensembl release 89: ENSG00000167780 - Ensembl, May 2017
  2. ^ Jump up to: a b c GRCm38: Ensembl release 89: ENSMUSG00000023045 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jump up to: a b "Entrez Gene: SOAT2 sterol O-acyltransferase 2".

Further reading[]


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