SOCS4

SOCS4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IZV
Identifiers
Aliases	SOCS4, SOCS7, suppressor of cytokine signaling 4
External IDs	OMIM: 616337 MGI: 1914546 HomoloGene: 15442 GeneCards: SOCS4
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.3 Start 55,027,230 bp[1] End 55,049,489 bp[1]
Gene ontology Molecular function • protein kinase inhibitor activity • GO:0001948 protein binding Cellular component • cytoplasm • intracellular anatomical structure Biological process • negative regulation of epidermal growth factor-activated receptor activity • regulation of growth • negative regulation of signal transduction • GO:0007243 intracellular signal transduction • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • protein ubiquitination • cytokine-mediated signaling pathway • negative regulation of receptor signaling pathway via JAK-STAT Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	122809	67296
Ensembl	ENSG00000180008	ENSMUSG00000048379
UniProt	Q8WXH5	Q91ZA6
RefSeq (mRNA)	NM_080867 NM_199421	NM_080843
RefSeq (protein)	NP_543143 NP_955453	NP_543119
Location (UCSC)	Chr 14: 55.03 – 55.05 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.^[4]

Function[]

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

References[]

Further reading[]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links[]

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Suppressor of cytokine signaling 4 (SOCS4)

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by .

• v
• t