SPDEF

SPDEF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DKX
Identifiers
Aliases	SPDEF, PDEF, bA375E1.3, SAM pointed domain containing ETS transcription factor
External IDs	OMIM: 608144 MGI: 1353422 HomoloGene: 8231 GeneCards: SPDEF
Gene location (Human)
Chr.	Chromosome 6 (human)
End	34,556,333 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	27,947,929 bp
RNA expression pattern
	Top expressed in
	prostate; ; salivary gland; ; minor salivary gland; ; parotid gland; ; fundus; ; stomach;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; DNA binding; GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; cell differentiation; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; negative regulation of cell fate commitment; lung goblet cell differentiation; intestinal epithelial cell development; transcription, DNA-templated; positive regulation of cell fate commitment; positive regulation of transcription by RNA polymerase II; positive regulation of apoptotic process; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	25803
	30051
	ENSG00000124664
	ENSMUSG00000024215
	O95238
	Q9WTP3
	NM_001252294; NM_012391
	NM_013891; NM_001357728
	NP_001239223; NP_036523
	NP_038919; NP_001344657
	Wikidata
View/Edit Human	View/Edit Mouse

SAM pointed domain-containing Ets transcription factor is a protein that in humans is encoded by the SPDEF gene.^[5]^[6]^[7]

PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM]^[7]

Interactions[]

SPDEF has been shown to interact with NKX3-1.^[8]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124664 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024215 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Oettgen P; Finger E; Sun Z; Akbarali Y; Thamrongsak U; Boltax J; Grall F; Dube A; Weiss A; Brown L; Quinn G; Kas K; Endress G; Kunsch C; Libermann TA (February 2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". J Biol Chem. 275 (2): 1216–25. doi:10.1074/jbc.275.2.1216. PMID 10625666.
^ Johannessen JV; Finseth I (July 1983). "Electron micrographs in five minutes". Ultrastruct Pathol. 4 (1): 97–100. doi:10.3109/01913128309140576. PMID 6857767.
^ ^a ^b "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor".
^ Chen, Hui; Nandi Asit K; Li Xiang; Bieberich Charles J (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. United States. 62 (2): 338–40. ISSN 0008-5472. PMID 11809674.

Further reading[]

Lance V (1976). "Studies on the annual reproductive cycle of the female cobra, Naja naja. Seasonal variation in plasma inorganic ions". Comparative Biochemistry and Physiology A. 53 (3): 285–9. doi:10.1016/S0300-9629(76)80037-0. PMID 2437.
Yamada N; Tamai Y; Miyamoto H; Nozaki M (2000). "Cloning and expression of the mouse Pse gene encoding a novel Ets family member". Gene. 241 (2): 267–74. doi:10.1016/S0378-1119(99)00484-9. PMID 10675039.
Chen H; Nandi AK; Li X; Bieberich CJ (2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. 62 (2): 338–40. PMID 11809674.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Thompson HG, Harris JW, Wold BJ, et al. (2003). "p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells". Oncogene. 22 (15): 2322–33. doi:10.1038/sj.onc.1206325. PMID 12700667.
Feldman RJ, Sementchenko VI, Gayed M, et al. (2003). "Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression". Cancer Res. 63 (15): 4626–31. PMID 12907642.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ghadersohi A, Odunsi K, Lele S, et al. (2004). "Prostate derived Ets transcription factor shows better tumor-association than other cancer-associated molecules". Oncol. Rep. 11 (2): 453–8. doi:10.3892/or.11.2.453. PMID 14719083.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chen H; Bieberich CJ (2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF". J. Cell. Biochem. 94 (1): 168–77. doi:10.1002/jcb.20297. PMID 15523673. S2CID 46494570.
Wang Y, Feng L, Said M, et al. (2005). "Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site". Biochemistry. 44 (19): 7095–106. doi:10.1021/bi047352t. PMID 15882048.
Fowler M, Borazanci E, McGhee L, et al. (2006). "RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region". J. Cell. Biochem. 97 (1): 1–17. doi:10.1002/jcb.20664. PMID 16237704. S2CID 20541109.
Gunawardane RN, Sgroi DC, Wrobel CN, et al. (2006). "Novel role for PDEF in epithelial cell migration and invasion". Cancer Res. 65 (24): 11572–80. doi:10.1158/0008-5472.CAN-05-1196. PMC 2919290. PMID 16357167.
Rodabaugh KJ, Mhawech-Fauceglia P, Groth J, et al. (2007). "Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors". Int. J. Gynecol. Pathol. 26 (1): 10–5. doi:10.1097/01.pgp.0000225386.41244.bd. PMID 17197890. S2CID 25880565.
Park KS, Korfhagen TR, Bruno MD, et al. (2007). "SPDEF regulates goblet cell hyperplasia in the airway epithelium". J. Clin. Invest. 117 (4): 978–88. doi:10.1172/JCI29176. PMC 1810569. PMID 17347682.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124664 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024215 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10625666-5] Oettgen P; Finger E; Sun Z; Akbarali Y; Thamrongsak U; Boltax J; Grall F; Dube A; Weiss A; Brown L; Quinn G; Kas K; Endress G; Kunsch C; Libermann TA (February 2000). "PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression". J Biol Chem. 275 (2): 1216–25. doi:10.1074/jbc.275.2.1216. PMID 10625666.

[pmid6857767-6] Johannessen JV; Finseth I (July 1983). "Electron micrographs in five minutes". Ultrastruct Pathol. 4 (1): 97–100. doi:10.3109/01913128309140576. PMID 6857767.

[entrez-7] "Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor".

[pmid11809674-8] Chen, Hui; Nandi Asit K; Li Xiang; Bieberich Charles J (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter". Cancer Res. United States. 62 (2): 338–40. ISSN 0008-5472. PMID 11809674.

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