SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[6]
^Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID12027893.
Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B (May 2006). "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer". The Prostate. 66 (6): 613–24. doi:10.1002/pros.20353. PMID16388505. S2CID43803094.
Ding W, Bellusci S, Shi W, Warburton D (Jul 2004). "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis". American Journal of Physiology. Lung Cellular and Molecular Physiology. 287 (1): L52-9. doi:10.1152/ajplung.00430.2003. PMID14977631.
Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology. 5 (5): 427–32. doi:10.1038/ncb978. PMID12717443. S2CID33846459.
Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID12027893.
External links[]
PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein sprouty homolog 4 (SPRY4)
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