ST6GALNAC2

ST6GALNAC2
Identifiers
Aliases	ST6GALNAC2, SAITL1, SIAT7, SIAT7B, SIATL1, ST6GalNAII, STHM, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
External IDs	OMIM: 610137 MGI: 107553 HomoloGene: 4714 GeneCards: ST6GALNAC2
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,586,956 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,585,694 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; olfactory bulb; ; tibial nerve; ; fallopian tube; ; vagina; ; trigeminal ganglion; ; testicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; sialyltransferase activity; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane;
Biological process	sialylation; oligosaccharide metabolic process; O-glycan processing; protein N-linked glycosylation via asparagine; protein glycosylation; protein O-linked glycosylation; protein sialylation;
	Sources:Amigo / QuickGO
Orthologs
	10610
	20446
	ENSG00000070731
	ENSMUSG00000057286
	Q9UJ37
	P70277
	NM_006456
	NM_009180
	NP_006447
	NP_033206
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 is an enzyme that in humans is encoded by the ST6GALNAC2 gene.^[5]^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000070731 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057286 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sotiropoulou G, Kono M, Anisowicz A, Stenman G, Tsuji S, Sager R (May 2002). "Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer". Mol Med. 8 (1): 42–55. doi:10.1007/BF03402002. PMC 2039932. PMID 11984005.
^ "Entrez Gene: ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2".

Further reading[]

Li GS, Zhu L, Zhang H, et al. (2007). "Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy". Hum. Mutat. 28 (10): 950–7. doi:10.1002/humu.20543. PMID 17480010. S2CID 7286057.
Raska M, Moldoveanu Z, Suzuki H, et al. (2007). "Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells". J. Mol. Biol. 369 (1): 69–78. doi:10.1016/j.jmb.2007.03.002. PMC 1995659. PMID 17418236.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Samyn-Petit B, Krzewinski-Recchi MA, Steelant WF, et al. (2000). "Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells". Biochim. Biophys. Acta. 1474 (2): 201–11. doi:10.1016/s0304-4165(00)00020-9. PMID 10742600.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000070731 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057286 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11984005-5] Sotiropoulou G, Kono M, Anisowicz A, Stenman G, Tsuji S, Sager R (May 2002). "Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer". Mol Med. 8 (1): 42–55. doi:10.1007/BF03402002. PMC 2039932. PMID 11984005.

[entrez-6] "Entrez Gene: ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2".

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