Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene .[5] [6]
Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by ST8SIA1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.[6]
In melanocytic cells, ST8SIA1 gene expression may be regulated by MITF .[7]
References [ ]
^ a b c GRCh38: Ensembl release 89: ENSG00000111728 - Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030283 - Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Sasaki K, Watanabe E, Kawashima K, Sekine S, Dohi T, Oshima M, Hanai N, Nishi T, Hasegawa M (Dec 1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection" . J Biol Chem . 268 (30): 22782–7. doi :10.1016/S0021-9258(18)41595-5 . PMID 7901202 .
^ a b "Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1" .
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy" . Pigment Cell Melanoma Res . 21 (6): 665–76. doi :10.1111/j.1755-148X.2008.00505.x . PMID 19067971 . S2CID 24698373 .
Further reading [ ]
Haraguchi M, Yamashiro S, Yamamoto A, et al. (1994). "Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody" . Proc. Natl. Acad. Sci. U.S.A . 91 (22): 10455–9. Bibcode :1994PNAS...9110455H . doi :10.1073/pnas.91.22.10455 . PMC 45039 . PMID 7937974 .
Nara K, Watanabe Y, Maruyama K, et al. (1994). "Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells" . Proc. Natl. Acad. Sci. U.S.A . 91 (17): 7952–6. Bibcode :1994PNAS...91.7952N . doi :10.1073/pnas.91.17.7952 . PMC 44522 . PMID 8058740 .
Sasaki K, Kurata K, Kojima N, et al. (1994). "Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase)" . J. Biol. Chem . 269 (22): 15950–6. doi :10.1016/S0021-9258(17)40773-3 . PMID 8195250 .
Nakayama J, Fukuda MN, Hirabayashi Y, et al. (1996). "Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme" . J. Biol. Chem . 271 (7): 3684–91. doi :10.1074/jbc.271.7.3684 . PMID 8631981 .
Matsuda Y, Nara K, Watanabe Y, et al. (1996). "Chromosome mapping of the GD3 synthase gene (SIAT8) in human and mouse". Genomics . 32 (1): 137–9. doi :10.1006/geno.1996.0090 . PMID 8786103 .
De Maria R, Lenti L, Malisan F, et al. (1997). "Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis". Science . 277 (5332): 1652–5. doi :10.1126/science.277.5332.1652 . PMID 9287216 .
Angata K, Suzuki M, McAuliffe J, et al. (2000). "Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III" . J. Biol. Chem . 275 (24): 18594–601. doi :10.1074/jbc.M910204199 . PMID 10766765 .
Zeng G, Gao L, Suetake K, et al. (2002). "Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed". Cancer Lett . 178 (1): 91–8. doi :10.1016/S0304-3835(01)00817-5 . PMID 11849746 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Furukawa K, Horie M, Okutomi K, et al. (2003). "Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene". Biochim. Biophys. Acta . 1627 (2–3): 71–8. doi :10.1016/s0167-4781(03)00076-9 . PMID 12818424 .
Moon SK, Kim HM, Lee YC, Kim CH (2004). "Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression" . J. Biol. Chem . 279 (32): 33063–70. doi :10.1074/jbc.M313462200 . PMID 15175338 .
Ha KT, Lee YC, Kim CH (2004). "Overexpression of GD3 synthase induces apoptosis of vascular endothelial ECV304 cells through downregulation of Bcl-2" . FEBS Lett . 568 (1–3): 183–7. doi :10.1016/j.febslet.2004.05.020 . PMID 15196944 . S2CID 34782656 .
Tomassini B, Malisan F, Franchi L, et al. (2005). "Calnexin suppresses GD3 synthase-induced apoptosis". FASEB J . 18 (13): 1553–5. doi :10.1096/fj.04-1675fje . PMID 15319364 . S2CID 44936219 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Teintenier-Lelièvre M, Julien S, Juliant S, et al. (2006). "Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins" . Biochem. J . 392 (Pt 3): 665–74. doi :10.1042/BJ20051120 . PMC 1316308 . PMID 16120058 .
Kang NY, Kang Y, Kang SK, et al. (2006). "Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-kappaB in regulated expression" . Glycobiology . 16 (5): 375–89. doi :10.1093/glycob/cwj087 . PMID 16481330 .
Ko K, Furukawa K, Takahashi T, et al. (2006). "Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers" . Oncogene . 25 (52): 6924–35. doi :10.1038/sj.onc.1209683 . PMID 16862187 .
Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities" . Med. Res. Rev . 37 (2): 210–270. doi :10.1002/med.21407 . PMID 27678392 . S2CID 26280291 .