SUPV3L1

SUPV3L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RC3, 3RC8
Identifiers
Aliases	SUPV3L1, SUV3, Suv3 like RNA helicase
External IDs	OMIM: 605122 MGI: 2441711 HomoloGene: 2386 GeneCards: SUPV3L1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 69,180,234 bp[1] End 69,209,099 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 62,264,988 bp[2] End 62,285,517 bp[2]
RNA expression pattern Bgee Top expressed in cerebellar hemisphere anterior pituitary testicle nucleus accumbens body of stomach gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding nucleotide binding protein homodimerization activity GO:0008026 helicase activity GO:0034459 3'-5' RNA helicase activity hydrolase activity, acting on acid anhydrides GO:0004003 DNA helicase activity GO:0001948 protein binding double-stranded RNA binding ATP binding hydrolase activity RNA binding Cellular component mitochondrial degradosome mitochondrial matrix mitochondrion mitochondrial nucleoid nucleus Biological process DNA recombination mitochondrial mRNA catabolic process mitochondrial ncRNA surveillance mitochondrial RNA 3'-end processing RNA catabolic process negative regulation of apoptotic process positive regulation of cell growth DNA duplex unwinding mitochondrial mRNA surveillance mitochondrion morphogenesis mitochondrial RNA surveillance positive regulation of mitochondrial RNA catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6832	338359
Ensembl	ENSG00000156502	ENSMUSG00000020079
UniProt	Q8IYB8	Q80YD1
RefSeq (mRNA)	NM_001301683 NM_003171 NM_001323584 NM_001323585 NM_001323586 NM_001323587 NM_001323588	NM_181423 NM_001359806
RefSeq (protein)	NP_001288612 NP_001310513 NP_001310514 NP_001310515 NP_001310516 NP_001310517 NP_003162	NP_852088 NP_001346735
Location (UCSC)	Chr 10: 69.18 – 69.21 Mb	Chr 10: 62.26 – 62.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

ATP-dependent RNA helicase SUPV3L1, mitochondrial is an enzyme that in humans is encoded by the SUPV3L1 gene.^[5][6][7]

Model organisms[]

Model organisms have been used in the study of SUPV3L1 function. A conditional knockout mouse line, called Supv3l1^{tm1a(EUCOMM)Wtsi[13][14]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.^[15][16][17]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[11][18] Twenty six tests were carried out and three significant phenotypes were reported. All homozygous mutant animals died prior to birth, and therefore none were observed at weaning. The remaining tests were carried out on heterozygous mutant mice and radiography showed female animals had defects in their transverse processes.^[11]

References[]

Further reading[]

External links[]

• Overview of all the structural information available in the PDB for UniProt: Q8IYB8 (ATP-dependent RNA helicase SUPV3L1, mitochondria) at the PDBe-KB.

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