Sentinel cell

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Sentinel cells refer to cells in the body's first line of defense, which embed themselves in tissues such as skin.^[1] Sentinel cells can refer to specific antigen-presenting cells, such as:

• Macrophages
  • Kupffer cells - in the liver
  • Langerhans cells - in the skin and mucosa (*these are a form of dendritic cells)
  • Alveolar macrophages - in the lungs
  • Microglia - in the brain
• Dendritic cells

Sentinel cells can also refer to cells that are normally not specialized antigen-presenting cells such as:^[1]

• Mast cells
• Specialized T cells

Sometimes tissue cells not part of the immune system such as are also referred to as Sentinel cells:^[1]

• Fibroblasts
• Epithelial cells

References[]

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