Serrate RNA effector molecule homolog

SRRT
Identifiers
Aliases	SRRT, ARS2, ASR2, serrate, serrate, RNA effector molecule
External IDs	OMIM: 614469 MGI: 1933527 HomoloGene: 9298 GeneCards: SRRT
Gene location (Human)
Chr.	Chromosome 7 (human)
End	100,888,664 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,305,936 bp
RNA expression pattern
	Top expressed in
	testicle; ; cerebellar hemisphere; ; anterior pituitary; ; sural nerve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; GO:0001948 protein binding; nucleic acid binding; RNA binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; protein-containing complex;
Biological process	positive regulation of neurogenesis; gene silencing; cell population proliferation; regulation of transcription, DNA-templated; response to arsenic-containing substance; transcription, DNA-templated; neuronal stem cell population maintenance; primary miRNA processing; mRNA splicing, via spliceosome; snRNA transcription by RNA polymerase II; mRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	51593
	83701
	ENSG00000087087
	ENSMUSG00000037364
	Q9BXP5
	Q99MR6
	NM_001128852; NM_001128853; NM_001128854; NM_015908; NM_182800
	NM_001109909; NM_001109910; NM_031405; NM_001359602
	NP_001122324; NP_001122325; NP_001122326; NP_056992
	NP_001103379; NP_001103380; NP_113582; NP_001346531
	Wikidata
View/Edit Human	View/Edit Mouse

Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.^[5]

The SRRT gene product plays a role in RNA-mediated gene silencing (RNAi) by miRNAs. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewal, by directly binding the SOX2 promoter and positively regulating its transcription.

It does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Diseases associated with SRRT include spondylocostal dysostosis.

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000087087 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037364 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ARS2 ARS2 protein".

Further reading[]

Rossman TG, Wang Z (1999). "Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis". Carcinogenesis. 20 (2): 311–6. doi:10.1093/carcin/20.2.311. PMID 10069470.
Wilson MD, Riemer C, Martindale DW, et al. (2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5". Nucleic Acids Res. 29 (6): 1352–65. doi:10.1093/nar/29.6.1352. PMC 29746. PMID 11239002.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Di Y, Li J, Zhang Y, et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins". J. Biochem. 133 (6): 713–8. doi:10.1093/jb/mvg091. PMID 12869526.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000087087 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037364 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ARS2 ARS2 protein".

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