Small nucleolar RNA R21

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Small nucleolar RNA R21
RF00352.jpg
Predicted secondary structure and sequence conservation of snoR21
Identifiers
SymbolsnoR21
RfamRF00352
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0001263
PDB structuresPDBe

In molecular biology, Small nucleolar RNA R21 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA R21 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] Plant snoRNA R21 was identified in a screen of Arabidopsis thaliana .[2]

References[]

  1. ^ Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ^ Barneche F, Gaspin C, Guyot R, Echeverría M (2001). "Identification of 66 box C/D snoRNAs in Arabidopsis thaliana: extensive gene duplications generated multiple isoforms predicting new ribosomal RNA 2'-O-methylation sites". J. Mol. Biol. 311 (1): 57–73. doi:10.1006/jmbi.2001.4851. PMID 11469857.

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