Staufen (protein)

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Structures	Swiss-model
Domains	InterPro

Maternal effect protein staufen
Maternal effect protein staufen
Identifiers
Organism	Drosophila melanogaster
Symbol	stau
UniProt	P25159
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Staufen is a protein product of a maternally expressed gene in Drosophila melanogaster that has been implicated in helping regulate genes important in determination of gradients that set up the anterior posterior axis such as bicoid and oskar. It is involved in targeting of the messenger RNA encoding these genes to the correct pole of the egg cell.^[1]^[2]

Human homologs of this protein include STAU1 and STAU2.

Localization of Staufen (Stau:GFP) in Drosophila stage 9 oocytes (white arrow).

References[]

^ Kelsey C. Martin, Anne Ephrussi (2009) Cell 136, 719–730. mRNA Localization: Gene Expression in the Spatial Dimension.
^ Bahram Houchmandzadeh, Eric Wieschaus, and Stanislas Leibler (2002) Nature 415, 798-802. Establishment of developmental precision and proportions in the early Drosophila embryo.

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[1] Kelsey C. Martin, Anne Ephrussi (2009) Cell 136, 719–730. mRNA Localization: Gene Expression in the Spatial Dimension.

[2] Bahram Houchmandzadeh, Eric Wieschaus, and Stanislas Leibler (2002) Nature 415, 798-802. Establishment of developmental precision and proportions in the early Drosophila embryo.

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