Stephen C. Harrison
This biography of a living person needs additional citations for verification. (February 2013) |
Stephen Harrison | |
---|---|
Born | Stephen C. Harrison |
Alma mater | Harvard University (BA, PhD) |
Spouse(s) | Tomas Kirchhausen |
Website | crystal |
Stephen C. Harrison is professor of biological chemistry and molecular pharmacology, professor of pediatrics, and director of the Center for Molecular and Cellular Dynamics of Harvard Medical School, head of the Laboratory of Molecular Medicine at Boston Children's Hospital, and investigator of the Howard Hughes Medical Institute.[1]
Education and career[]
He received his B.A. in chemistry and physics from Harvard in 1963, and was then a Henry fellow at the MRC Laboratory of Molecular Biology at Cambridge. In 1967, he received his Ph.D. in biophysics from Harvard, was a research fellow there as well as a junior fellow in the Society of Fellows, and joined the Harvard faculty in 1971.
Research[]
His wide-ranging studies of protein structure have contributed insights to viral architecture, DNA–protein recognition, and cellular signaling.
Harrison has made important contributions to structural biology, most notably by determining and analyzing the structures of viruses and viral proteins, by crystallographic analysis of protein–DNA complexes,[2][3] and by structural studies of protein-kinase switching mechanisms.[4] The initiator of high-resolution virus crystallography, he has moved from his early work on tomato bushy stunt virus[5] (1978) to the study of more complex human pathogens, including the capsid of human papillomavirus,[6] the envelope of dengue virus,[7] and several components of HIV.[8] He has also turned some of his research attention to even more complex assemblies, such as clathrin-coated vesicles.[9] He led the Structural Biology team at the Center for HIV/AIDS Vaccine Immunology (CHAVI) when it received National Institute of Allergy and Infectious Diseases (NIAID) funding [10] of around $300 million to address key immunological roadblocks to HIV vaccine development and to design, develop and test novel HIV vaccine candidates.
Society memberships[]
He is a member of American Academy of Arts and Sciences, National Academy of Sciences, American Philosophical Society, European Molecular Biology Organization, American Crystallographic Association and American Association for the Advancement of Science.
Awards[]
- 1982 Ledlie Prize, Harvard University
- 1988 Wallace P. Rowe Award, National Institute of Allergy and Infectious Diseases
- 1990 Louisa Gross Horwitz Prize (with Don Wiley and Michael Rossmann), Columbia University
- 1990 Harvey Lecturer, The Harvey Society, New York
- 1995 George Ledlie Prize, Harvard University
- 1997
- 2001 Paul Ehrlich and Ludwig Darmstaedter Prize (with Michael Rossmann)
- 2005 Bristol-Myers Squibb Award for Distinguished Achievement in Infectious Diseases Research
- 2006 Gregori Aminoff Prize in Crystallography (with David Stuart)
- 2007 UCSD/Merck Life Sciences Achievement Award[11]
- 2011 William Silen Lifetime Achievement in Mentoring Award, Harvard Medical School[12]
- 2012 Pauling Lectureship, Stanford University
- 2014 Elected as a Foreign Member of the Royal Society of London.[13]
- 2015 The Welch Award in Chemistry
- 2015 Honorary Doctorate in Medicine, University of Milan
- 2018 48th Rosenstiel Award for research on proteins and viruses.[14]
Personal life[]
Harrison met his husband Tomas Kirchhausen in 1979. They married in 2013.[15]
References[]
- ^ "Awards - Stephen C. Harrison wins Bristol-Myers Squibb infectious diseases r". Newsrx.com. 2005-08-22. Retrieved 2013-01-29.
- ^ Anderson JE, Ptashne M, Harrison SC (1987). "Structure of the repressor-operator complex of bacteriophage 434". Nature. 326 (6116): 846–52. doi:10.1038/326846a0. PMID 3553959. S2CID 4259005.
- ^ Ellenberger TE, Brandl CJ, Struhl K, Harrison SC (December 1992). "The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex". Cell. 71 (7): 1223–37. doi:10.1016/s0092-8674(05)80070-4. PMID 1473154. S2CID 13548424.
- ^ Xu W, Harrison SC, Eck MJ (February 1997). "Three-dimensional structure of the tyrosine kinase c-Src". Nature. 385 (6617): 595–602. doi:10.1038/385595a0. PMID 9024657. S2CID 4365051.
- ^ Harrison SC (June 1969). "Structure of tomato bushy stunt virus. I. The spherically averaged electron density". J. Mol. Biol. 42 (3): 457–83. doi:10.1016/0022-2836(69)90236-8. PMID 5804155.
- ^ Modis Y, Trus BL, Harrison SC (September 2002). "Atomic model of the papillomavirus capsid". EMBO J. 21 (18): 4754–62. doi:10.1093/emboj/cdf494. PMC 126290. PMID 12234916.
- ^ Modis Y, Ogata S, Clements D, Harrison SC (January 2004). "Structure of the dengue virus envelope protein after membrane fusion". Nature. 427 (6972): 313–9. doi:10.1038/nature02165. PMID 14737159. S2CID 4334063.
- ^ Huang H, Chopra R, Verdine GL, Harrison SC (November 1998). "Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance". Science. 282 (5394): 1669–75. doi:10.1126/science.282.5394.1669. PMID 9831551.
- ^ "Archived copy". Archived from the original on 2014-05-14. Retrieved 2013-01-12.CS1 maint: archived copy as title (link)
- ^ "NIAID Funds Center for HIV/AIDS Vaccine Immunology (CHAVI)". Niaid.nih.gov. 2005-07-14. Retrieved 2013-01-29.
- ^ "UCSD, Harvard Biologist Named Recipient of 2007 UCSD/Merck Life Sciences Achievement Award, March 27, 2007".
- ^ "Harvard Medical School, William Silen Lifetime Achievement Excellence in Mentoring Awards Recipients".
- ^ "Professor Stephen Harrison ForMemRS".
- ^ "BrandeisNOW, Lawrence Goodman, Oct. 15, 2018".
- ^ Harrison, Stephen C. (2015-06-02). "Veritas per structuram". Annual Review of Biochemistry. 84 (1): 37–60. doi:10.1146/annurev-biochem-060614-033857. ISSN 0066-4154. PMID 25494302.
- Structural biology
- Crystallographers
- HIV/AIDS researchers
- Harvard University alumni
- Members of the United States National Academy of Sciences
- Howard Hughes Medical Investigators
- Living people
- Foreign Members of the Royal Society
- LGBT scientists from the United States