Sydney M. Finegold

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Sydney "Sid" Martin Finegold (August 21, 1921, Far Rockaway, Queens, New York City – September 17, 2018, Los Angeles) was an American physician, medical school professor, and medical researcher, specializing in anaerobic bacteriology.

Biography[]

Born in New York City to Russian, Jewish immigrant parents who worked as pharmacists, Sydney Finegold had a sister and an older brother. The family moved to Los Angeles in the early 1930s.[1] Sydney Finegold graduated in 1943 from the University of California, Los Angeles (UCLA) with a bacteriology major and served from 1943 to 1945 in the US Marine Corps.[2] After WWII ended, he matriculated at the University of Texas Medical Branch in Galveston, where he graduated in 1949 with an M.D.[3] In 1947 he married Mary Louise Saunders, a fellow medical student.[2][3] From 1949 to 1950 he was a medical intern in internal medicine at the US Public Health Service in Galveston.[2] From 1950 to 1952 he was a resident in internal medicine at the University of Minnesota Medical School, where he was mentored by Wesley W. Spink and Wendell H. Hall.[2][3] From 1951 to 1952 Finegold held his first faculty appointment at the University of Minnesota Medical School.[2] During the Korean War he was recalled to military service. From 1952 to 1953 he was a regimental surgeon in the US Army in Japan and Korea.[2] From 1953 to 2000 he was a physician at the Wadsworth VA Hospital, Los Angeles. During the beginning of his career there he was mentored by William L. Hewitt. From 1968 to 2000 Finegold was Professor of Medicine, Microbiology, Immunology and Molecular Genetics at the UCLA School of Medicine.[3] From 1990 to 2000 he was the editor-in-chief of the journal Clinical Infectious Diseases (which before 1992 was named Reviews of Infectious Diseases).[2][4]

His studies on fecal flora and the role of anaerobes in the blind loop syndrome and the effects of diet on fecal flora led to an understanding of the effects of surgery, pharmaceuticals, and other factors in the development of disease as a result of the alternation of bowel flora. Finegold and his colleagues later identified Clostridium difficile as the causative agent of pseudomembranous colitis, establishing it as one of the most significant causes of nosocomial disease associated with morbidity and mortality.[5]

Finegold contributed over 600 scientific articles, review articles and book chapters and served as author or editor of 30+ books and monographs. His works include the highly-renowned reference guide, Anaerobic Infections in Humans, coedited with W. Lance George, the first Wadsworth Anaerobic Bacteriology Manual (1972), with Vera Sutter and colleagues, and the 8th edition of Bailey and Scott’s Diagnostic Microbiology, coedited with Ellen Jo Baron (1990), a text used extensively in clinical microbiology laboratories worldwide.[6]

Dr. Finegold was in 1963 a founding member of the Infectious Diseases Society of America (IDSA), in 1981–1982 the IDSA's president, and in 1987 the recipient of the IDSA's Alexander Fleming Award for Lifetime Achievement.[6] In 1971 he was elected a Fellow of the American Association for the Advancement of Science.[7] In 1999 he received the Becton-Dickinson Award in Clinical Microbiology.[8]

He was predeceased by his first wife.[9] They had two sons and daughters. In 1994 he married Gloria Helene Weiss.[2] Upon his death he was survived by his three children, four grandchildren, two great-grandchildren, and a longtime companion.[9]

Eponyms[]

Genus[]

Species[]

Selected publications[]

  • Kent, John R.; Finegold, Sydney M. (1960). "Human Rabies Transmitted by the Bite of a Bat". New England Journal of Medicine. 263 (21): 1058–1065. doi:10.1056/NEJM196011242632106. PMID 13752554.
  • Finegold, Sydney M.; Gaylor, Donald W. (1960). "Enterocolitis Due to Phage Type 54 Staphylococci Resistant to Kanamycin, Neomycin, Paromomycin and Chloramphenicol". New England Journal of Medicine. 263 (22): 1110–1116. doi:10.1056/NEJM196012012632204. PMID 13699584.
  • Scott, James L.; Finegold, Sydney M.; Belkin, Gerald A.; Lawrence, John S. (1965). "A Controlled Double-Blind Study of the Hematologic Toxicity of Chloramphenicol". New England Journal of Medicine. 272 (22): 1137–1142. doi:10.1056/NEJM196506032722201. PMID 14284981.
  • Winn, William R.; White, M. L.; Carter, W. T.; Miller, A. B.; Finegold, S. M. (1966). "Rapid Diagnosis of Bacteremia with Quantitative Differential-Membrane Filtration Culture". JAMA: The Journal of the American Medical Association. 197 (7): 539–548. doi:10.1001/jama.1966.03110070063017. PMID 5329866.
  • Bartlett, John G.; Sutter, Vera L.; Finegold, Sydney M. (1972). "Treatment of Anaerobic Infections with Lincomycin and Clindamycin". New England Journal of Medicine. 287 (20): 1006–1010. doi:10.1056/NEJM197211162872002. PMID 4346707.
  • Bartlett, J. G.; Finegold, S. M. (1974). "Anaerobic infections of the lung and pleural space". American Review of Respiratory Disease. 110 (1): 56–77.
  • Sutter, Vera L.; Finegold, Sydney M. (1976). "Susceptibility of Anaerobic Bacteria to 23 Antimicrobial Agents". Antimicrobial Agents and Chemotherapy. 10 (4): 736–752. doi:10.1128/AAC.10.4.736. PMC 429823. PMID 984809.
  • Drenick, Ernst J.; Ament, Marvin E.; Finegold, Sydney M.; Corrodi, Peter; Passaro, Edward (1976). "Bypass Enteropathy". JAMA. 236 (3): 269. doi:10.1001/jama.1976.03270030023022.
  • Finegold, S. M.; Sutter, V. L.; Sugihara, P. T.; Elder, H. A.; Lehmann, S. M.; Phillips, R. L. (1977). "Fecal microbial flora in Seventh Day Adventist populations and control subjects". The American Journal of Clinical Nutrition. 30 (11): 1781–1792. doi:10.1093/ajcn/30.11.1781. PMID 920638.
  • Klein, Russell A.; Busch, D. F.; Wilson, S. E.; Flora, D. J.; Finegold, S. M. (1977). "Doxycycline in Abdominal Surgery". JAMA: The Journal of the American Medical Association. 238 (18): 1933–1935. doi:10.1001/jama.1977.03280190035023. PMID 578553.
  • Goldstein, E. J.; Citron, D. M.; Wield, B.; Blachman, U.; Sutter, V. L.; Miller, T. A.; Finegold, S. M. (1978). "Bacteriology of human and animal bite wounds". Journal of Clinical Microbiology. 8 (6): 667–672. doi:10.1128/jcm.8.6.667-672.1978. PMC 275321. PMID 744798.
  • Lewis, Robert P.; Sutter, Vera L.; Finegold, Sydney M. (1978). "Bone Infections Involving Anaerobic Bacteria". Medicine. 57 (4): 279–306. doi:10.1097/00005792-197807000-00001. PMID 207946. S2CID 23567242.
  • George, W. L.; Sutter, V. L.; Citron, D.; Finegold, S. M. (1979). "Selective and differential medium for isolation of Clostridium difficile". Journal of Clinical Microbiology. 9 (2): 214–219. doi:10.1128/jcm.9.2.214-219.1979. PMC 272994. PMID 429542.
  • George, W. Lance; Volpicelli, Nicholas A.; Stiner, Dana B.; Richman, Douglas D.; Liechty, E. Joseph; Mok, Henry Y. I.; Rolfe, Rial D.; Finegold, Sydney M. (1979). "Relapse of Pseudomembranous Colitis after Vancomycin Therapy". New England Journal of Medicine. 301 (8): 414–415. doi:10.1056/NEJM197908233010806. PMID 460343.
  • Brook, Itzhak; Finegold, S. M. (1979). "Bacteriology of Chronic Otitis Media". JAMA: The Journal of the American Medical Association. 241 (5): 487–488. doi:10.1001/jama.1979.03290310027008. PMID 759663.
  • Goldstein, Ellie J. C.; Lewis, R. P.; Sutter, V. L.; Finegold, S. M. (1979). "Erythromycin for Anaerobic Pleuropulmonary and Soft-Tissue Infections". JAMA: The Journal of the American Medical Association. 242 (5): 435–438. doi:10.1001/jama.1979.03300050025020. PMID 448959.
  • Kirby, B. D.; Snyder, K. M.; Meyer, R. D.; Finegold, S. M. (1980). "Legionnaires' disease: Report of sixty-five nosocomially acquired cases of review of the literature". Medicine. 59 (3): 188–205. doi:10.1097/00005792-198005000-00002. PMID 6997673. S2CID 7266440.
  • Goldstein, Ellie J. C.; Finegold, Sydney M.; Lewis, Robert P. (1980). "Treatment of Anaerobic Pleuropulmonary and Soft-Tissue Infections-Reply". JAMA: The Journal of the American Medical Association. 244 (2): 135. doi:10.1001/jama.1980.03310020016013.
  • Finegold, S.M.; Sutter, V.L.; Mathisen, G.E. (1983). "Chapter 1. Normal Indigenous Intestinal Flora". Human Intestinal Microflora in Health and Disease edited by David J. Hentges. Academic Press. pp. 3–31. ISBN 9780323138666.
  • Shands, Kathryn N.; Ho, J. L.; Meyer, R. D.; Gorman, G. W.; Edelstein, P. H.; Mallison, G. F.; Finegold, S. M.; Fraser, D. W. (1985). "Potable Water as a Source of Legionnaires' Disease". JAMA: The Journal of the American Medical Association. 253 (10): 1412–1416. doi:10.1001/jama.1985.03350340064018. PMID 3968771.
  • Finegold, Sydney M. (1988). "Legionnaires' Disease—Still with Us". New England Journal of Medicine. 318 (9): 571–573. doi:10.1056/NEJM198803033180908. PMID 3340137.
  • Baron, E. J.; Summanen, P.; Downes, J.; Roberts, M. C.; Wexler, H.; Finegold, S. M. (1989). "Bilophila wadsworthia, gen. Nov. And sp. Nov., a Unique Gram-negative Anaerobic Rod Recovered from Appendicitis Specimens and Human Faeces". Microbiology. 135 (12): 3405–3411. doi:10.1099/00221287-135-12-3405. PMID 2636263.
  • Bennion, R. S.; Baron, E. J.; Thompson Jr, J. E.; Downes, J.; Summanen, P.; Talan, D. A.; Finegold, S. M. (1990). "The bacteriology of gangrenous and perforated appendicitis--revisited". Annals of Surgery. 211 (2): 165–171. doi:10.1097/00000658-199002000-00008. PMC 1357960. PMID 2405791.
  • Sandler, Richard H.; Finegold, Sydney M.; Bolte, Ellen R.; Buchanan, Cathleen P.; Maxwell, Anne P.; Väisänen, Marja-Liisa; Nelson, Michael N.; Wexler, Hannah M. (2000). "Short-Term Benefit from Oral Vancomycin Treatment of Regressive-Onset Autism". Journal of Child Neurology. 15 (7): 429–435. doi:10.1177/088307380001500701. PMID 10921511. S2CID 12507281.
  • Finegold, Sydney M.; Molitoris, Denise; Song, Yuli; Liu, Chengxu; Vaisanen, Marja‐Liisa; Bolte, Ellen; McTeague, Maureen; Sandler, Richard; Wexler, Hannah; Marlowe, Elizabeth M.; Collins, Matthew D.; Lawson, Paul A.; Summanen, Paula; Baysallar, Mehmet; Tomzynski, Thomas J.; Read, Erik; Johnson, Eric; Rolfe, Rial; Nasir, Palwasha; Shah, Haroun; Haake, David A.; Manning, Patricia; Kaul, Ajay (2002). "Gastrointestinal Microflora Studies in Late‐Onset Autism". Clinical Infectious Diseases. 35 (Suppl 1): S6–S16. doi:10.1086/341914. PMID 12173102.
  • Song, Yuli; Liu, Chengxu; Finegold, Sydney M. (2004). "Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children". Applied and Environmental Microbiology. 70 (11): 6459–6465. doi:10.1128/AEM.70.11.6459-6465.2004. PMC 525120. PMID 15528506.
  • Finegold, Sydney M.; Dowd, Scot E.; Gontcharova, Viktoria; Liu, Chengxu; Henley, Kathleen E.; Wolcott, Randall D.; Youn, Eunseog; Summanen, Paula H.; Granpeesheh, Doreen; Dixon, Dennis; Liu, Minghsun; Molitoris, Denise R.; Green, John A. (2010). "Pyrosequencing study of fecal microflora of autistic and control children". Anaerobe. 16 (4): 444–453. doi:10.1016/j.anaerobe.2010.06.008. PMID 20603222.
  • Finegold, Sydney M. (2011). "State of the art; microbiology in health and disease. Intestinal bacterial flora in autism". Anaerobe. 17 (6): 367–368. doi:10.1016/j.anaerobe.2011.03.007. PMID 21524713.
  • Finegold, Sydney M.; Downes, Julia; Summanen, Paula H. (2012). "Microbiology of regressive autism". Anaerobe. 18 (2): 260–262. doi:10.1016/j.anaerobe.2011.12.018. PMID 22202440.

References[]

  1. ^ Finegold, Sydney M. (2011). "A little kid from Far Rockaway grows up". Bulletin of the BISMiS. 2, part 2: 165–179.
  2. ^ a b c d e f g h "Lifetime Highlights: Sydney M. Finegold, MD". Clinical Infectious Diseases. 35: S3. 2002. doi:10.1086/341911.
  3. ^ a b c d e f Forbes, Betty A. (2012). "Biographical Feature: Sydney M. Finegold". Journal of Clinical Microbiology. 50 (8): 2546–2547. doi:10.1128/JCM.01295-12. PMC 3421517. PMID 22622446.
  4. ^ As editor-in-chief, Finegold was preceded by Edward H. Kass and succeeded by Sherwood Gorbach. Finegold, S. M. (1999). "Swan Song". Clinical Infectious Diseases. 29 (6): 1367–1368. doi:10.1086/313573.
  5. ^ "In Memoriam: Finegold, Sydney M. (1921–2018)". American Society for Microbiology.
  6. ^ a b "In Memoriam: Sydney "Sid" Finegold, MD, FIDSA 1921–2018". IDSA News. September 26, 2018.
  7. ^ "Historic Fellows Listing". American Association for the Advancement of Science.
  8. ^ "Awards, Center for the History of Microbiology/ASM Archives (CHOMA)". American Society for Microbiology.
  9. ^ a b "Obituary. Dr. Sydney M. Finegold". Los Angeles Times. September 19, 2018.

External links[]

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