T-cell lymphoma invasion and metastasis-inducing protein 1

TIAM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D8I, 3KZD, 3KZE, 4GVC, 4GVD, 4K2O, 4K2P, 4NXP, 4NXQ, 4NXR
Identifiers
Aliases	TIAM1, T-cell lymphoma invasion and metastasis-inducing protein 1, T-cell lymphoma invasion and metastasis 1
External IDs	OMIM: 600687 MGI: 103306 HomoloGene: 2443 GeneCards: TIAM1
Gene location (Mouse) Chr. Chromosome 16 (mouse)[1] Band 16 C3.3|16 51.5 cM Start 89,583,999 bp[1] End 89,940,657 bp[1]
RNA expression pattern Bgee n/a BioGPS More reference expression data
Gene ontology Molecular function microtubule binding kinase binding GO:0001948 protein binding lipid binding guanyl-nucleotide exchange factor activity receptor tyrosine kinase binding Cellular component cytoplasm cytosol membrane cell-cell junction cell-cell contact zone extrinsic component of cytoplasmic side of plasma membrane plasma membrane dendritic spine axonal growth cone synapse main axon ruffle membrane cell junction neuronal cell body somatodendritic compartment microtubule nucleus GO:0097483, GO:0097481 postsynaptic density glutamatergic synapse extrinsic component of postsynaptic density membrane Biological process protein localization to membrane apoptotic process regulation of insulin secretion involved in cellular response to glucose stimulus GO:0007243 intracellular signal transduction GO:0032861, GO:0032862, GO:0032856 activation of GTPase activity positive regulation of JUN kinase activity ephrin receptor signaling pathway cardiac muscle hypertrophy regulation of non-canonical Wnt signaling pathway positive regulation of axonogenesis neuron projection extension Wnt signaling pathway, planar cell polarity pathway regulation of dopaminergic neuron differentiation regulation of ERK1 and ERK2 cascade positive regulation of neuron projection development positive regulation of apoptotic process positive regulation of Schwann cell chemotaxis positive regulation of protein binding cell-matrix adhesion Rac protein signal transduction regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction cell migration positive regulation of dendritic spine morphogenesis signal transduction response to cocaine positive regulation of cell population proliferation positive regulation of cell migration NMDA selective glutamate receptor signaling pathway regulation of modification of postsynaptic actin cytoskeleton regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7074	21844
Ensembl	ENSG00000156299	ENSMUSG00000002489
UniProt	Q13009	Q60610
RefSeq (mRNA)	NM_003253	NM_001145886 NM_001145887 NM_009384
RefSeq (protein)	NP_003244 NP_001340613 NP_001340614 NP_001340615 NP_001340616 NP_001340617 NP_001340618 NP_001340619 NP_001340620 NP_001340621 NP_001340622 NP_001340623	n/a
Location (UCSC)	n/a	Chr 16: 89.58 – 89.94 Mb
PubMed search	[2]	[3]
Wikidata
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T-cell lymphoma invasion and metastasis-inducing protein 1 is a protein that in humans is encoded by the TIAM1 gene.^[4][5][6]

Structure[]

TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding .

Function[]

TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA.

Clinical significance[]

TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.

Interactions[]

T-cell lymphoma invasion and metastasis-inducing protein 1 has been shown to interact with ANK1,^[7] Myc,^[8] RAC1^[9][10] and PPP1R9B.^[11]

Tiam1 interacts also with para-cingulin, that plays a role in recruiting Tiam1 to junctions and thus activate Rac1 at epithelial junctions.^[12]

References[]

Further reading[]