Transforming acidic coiled-coil-containing protein 2 is a protein that in humans is encoded by the TACC2gene.[5][6]
Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.[6]
Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines". Genomics. 58 (2): 165–70. doi:10.1006/geno.1999.5829. PMID10366448.
Pu JJ, Li C, Rodriguez M, Banerjee D (2001). "Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells". Cytokine. 13 (3): 129–37. doi:10.1006/cyto.2000.0812. PMID11161455.
Lauffart B, Gangisetty O, Still IH (2003). "Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2". Genomics. 81 (2): 192–201. doi:10.1016/S0888-7543(02)00039-3. PMID12620397.
Sadek CM, Pelto-Huikko M, Tujague M, et al. (2004). "TACC3 expression is tightly regulated during early differentiation". Gene Expr. Patterns. 3 (2): 203–11. doi:10.1016/S1567-133X(02)00066-2. PMID12711550.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID16964243. S2CID14294292.
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