TAF15

TAF15
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2MMY
Identifiers
Aliases	TAF15, Npl3, RBP56, TAF2N, TAFII68, TATA-box binding protein associated factor 15
External IDs	OMIM: 601574 MGI: 1917689 HomoloGene: 131088 GeneCards: TAF15
Gene location (Human)
Chr.	Chromosome 17 (human)
End	35,864,615 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	83,506,743 bp
RNA expression pattern
	Top expressed in
	esophagus; ; adrenal gland; ; tendon; ; testicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; GO:0001948 protein binding; metal ion binding; nucleic acid binding; RNA binding;
Cellular component	cytoplasm; nucleolus; nucleus; nucleoplasm;
Biological process	positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	8148
	70439
	ENSG00000270647; ENSG00000276833
	ENSMUSG00000020680
	Q92804
	n/a
	NM_003487; NM_139215
	NM_027427
	NP_003478; NP_631961
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene.^[5]^[6]^[7]

Function[]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a subunit of TFIID present in a subset of TFIID complexes. Translocations involving chromosome 17 and chromosome 9, where the gene for the nuclear receptor CSMF is located, result in a gene fusion product that is an RNA binding protein associated with a subset of extraskeletal myxoid chondrosarcomas. Two transcripts encoding different isoforms have been identified.^[7]

Interactions[]

TAF15 has been shown to interact with:

POLR2C,^[8]
POLR2E,^[8]
POLR2G,^[8]
SAFB,^[9]
TAF11,^[8]
TAF13,^[8]
TAF5,^[8]
TAF7,^[8] and
TATA binding protein^[10]

References[]

^ ^a ^b ^c ENSG00000276833 GRCh38: Ensembl release 89: ENSG00000270647, ENSG00000276833 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020680 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Morohoshi F, Arai K, Takahashi EI, Tanigami A, Ohki M (November 15, 1996). "Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins". Genomics. 38 (1): 51–7. doi:10.1006/geno.1996.0591. PMID 8954779.
^ Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M (Dec 1998). "Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes". Gene. 221 (2): 191–8. doi:10.1016/S0378-1119(98)00463-6. PMID 9795213.
^ ^a ^b "Entrez Gene: TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa".
^ ^a ^b ^c ^d ^e ^f ^g Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L (Mar 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. 18 (3): 1489–97. doi:10.1128/mcb.18.3.1489. PMC 108863. PMID 9488465.
^ Townson SM, Kang K, Lee AV, Oesterreich S (Jun 2004). "Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domain". J. Biol. Chem. 279 (25): 26074–81. doi:10.1074/jbc.M313726200. PMID 15066997.
^ Hoffmann A, Roeder RG (Jul 1996). "Cloning and characterization of human TAF20/15. Multiple interactions suggest a central role in TFIID complex formation". J. Biol. Chem. 271 (30): 18194–202. doi:10.1074/jbc.271.30.18194. PMID 8663456.

External links[]

Overview of all the structural information available in the PDB for UniProt: Q92804 (TATA-binding protein-associated factor 2N) at the PDBe-KB.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] ENSG00000276833 GRCh38: Ensembl release 89: ENSG00000270647, ENSG00000276833 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020680 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8954779-5] Morohoshi F, Arai K, Takahashi EI, Tanigami A, Ohki M (November 15, 1996). "Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins". Genomics. 38 (1): 51–7. doi:10.1006/geno.1996.0591. PMID 8954779.

[pmid9795213-6] Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M (Dec 1998). "Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes". Gene. 221 (2): 191–8. doi:10.1016/S0378-1119(98)00463-6. PMID 9795213.

[entrez-7] "Entrez Gene: TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa".

[pmid9488465-8] ^ ^a ^b ^c ^d ^e ^f ^g Bertolotti A, Melot T, Acker J, Vigneron M, Delattre O, Tora L (Mar 1998). "EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes". Mol. Cell. Biol. 18 (3): 1489–97. doi:10.1128/mcb.18.3.1489. PMC 108863. PMID 9488465.

[pmid15066997-9] Townson SM, Kang K, Lee AV, Oesterreich S (Jun 2004). "Structure-function analysis of the estrogen receptor alpha corepressor scaffold attachment factor-B1: identification of a potent transcriptional repression domain". J. Biol. Chem. 279 (25): 26074–81. doi:10.1074/jbc.M313726200. PMID 15066997.

[pmid8663456-10] Hoffmann A, Roeder RG (Jul 1996). "Cloning and characterization of human TAF20/15. Multiple interactions suggest a central role in TFIID complex formation". J. Biol. Chem. 271 (30): 18194–202. doi:10.1074/jbc.271.30.18194. PMID 8663456.

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TAF15

Contents

Function[]

Interactions[]

References[]

Further reading[]

External links[]