TKTL1

TKTL1
Identifiers
Aliases	TKTL1, TKR, TKT2, transketolase-like 1, transketolase like 1
External IDs	OMIM: 300044 MGI: 1933244 HomoloGene: 8169 GeneCards: TKTL1
Gene location (Human)
Chr.	X chromosome (human)
End	154,330,350 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	73,252,106 bp
RNA expression pattern
	Top expressed in
	testicle; ; right ventricle; ; myocardium; ; left ventricle; ; heart;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; catalytic activity; metal ion binding; transketolase activity;
Cellular component	cytoplasm; nucleus;
Biological process	thiamine metabolic process; metabolism; glucose catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8277
	83553
	ENSG00000007350
	ENSMUSG00000031397
	P51854
	Q99MX0
	NM_012253; NM_001145933; NM_001145934
	NM_031379
	NP_001139405; NP_001139406; NP_036385
	NP_113556
	Wikidata
View/Edit Human	View/Edit Mouse

Transketolase-like protein 1 is an enzyme with a catalytic function that in humans is encoded by the TKTL1 gene.^[5]^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007350 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031397 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Coy JF, Dubel S, Kioschis P, Thomas K, Micklem G, Delius H, Poustka A (Feb 1997). "Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes". Genomics. 32 (3): 309–16. doi:10.1006/geno.1996.0124. PMID 8838793.
^ "Entrez Gene: TKTL1 transketolase-like 1".

Further reading[]

Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Coy JF, Dressler D, Wilde J, Schubert P (2005). "Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer". Clin. Lab. 51 (5–6): 257–73. PMID 15991799.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Langbein S, Zerilli M, Zur Hausen A, et al. (2006). "Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted". Br. J. Cancer. 94 (4): 578–85. doi:10.1038/sj.bjc.6602962. PMC 2361175. PMID 16465194.
Staiger WI, Coy JF, Grobholz R, et al. (2007). "Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer". Oncol. Rep. 16 (4): 657–61. doi:10.3892/or.16.4.657. PMID 16969476.
Zhang S, Yang JH, Guo CK, Cai PC (2007). "Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells". Cancer Lett. 253 (1): 108–14. doi:10.1016/j.canlet.2007.01.010. PMID 17321041.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007350 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031397 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8838793-5] Coy JF, Dubel S, Kioschis P, Thomas K, Micklem G, Delius H, Poustka A (Feb 1997). "Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes". Genomics. 32 (3): 309–16. doi:10.1006/geno.1996.0124. PMID 8838793.

[entrez-6] "Entrez Gene: TKTL1 transketolase-like 1".

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