TMED1

TMED1
Identifiers
Aliases	TMED1, IL1RL1LG, Il1rl1l, Tp24, p24g1, transmembrane p24 trafficking protein 1
External IDs	OMIM: 605395 MGI: 106201 HomoloGene: 21360 GeneCards: TMED1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,836,318 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,421,548 bp
RNA expression pattern
	Top expressed in
	stomach; ; muscle of leg; ; left ventricle; ; body of stomach; ; kidney; ; gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; GO:0001948 protein binding;
Cellular component	integral component of membrane; Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment membrane; endoplasmic reticulum-Golgi intermediate compartment; plasma membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; COPII-coated ER to Golgi transport vesicle;
Biological process	protein transport; signal transduction; cell-cell signaling; intracellular protein transport; endoplasmic reticulum to Golgi vesicle-mediated transport; Golgi organization;
	Sources:Amigo / QuickGO
Orthologs
	11018
	17083
	ENSG00000099203
	ENSMUSG00000032180
	Q13445
	Q3V009
	NM_006858
	NM_010744; NM_001324510
	NP_006849
	NP_001311439; NP_034874
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane emp24 domain-containing protein 1 is a protein that in humans is encoded by the TMED1 gene.^[5]^[6]^[7]

The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1). This protein lacks any similarity to other interleukin 1 ligands. The functional significance of its interaction with IL1RL1 is not known.^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099203 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032180 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chan WL, Pejnovic N, Lee CA, Al-Ali NA (Jul 2001). "Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes". J Immunol. 167 (3): 1238–44. doi:10.4049/jimmunol.167.3.1238. PMID 11466339.
^ Gayle MA, Slack JL, Bonnert TP, Renshaw BR, Sonoda G, Taguchi T, Testa JR, Dower SK, Sims JE (Jun 1996). "Cloning of a putative ligand for the T1/ST2 receptor". J Biol Chem. 271 (10): 5784–9. doi:10.1074/jbc.271.10.5784. PMID 8621446.
^ ^a ^b "Entrez Gene: TMED1 transmembrane emp24 protein transport domain containing 1".

Further reading[]

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099203 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032180 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11466339-5] Chan WL, Pejnovic N, Lee CA, Al-Ali NA (Jul 2001). "Human IL-18 receptor and ST2L are stable and selective markers for the respective type 1 and type 2 circulating lymphocytes". J Immunol. 167 (3): 1238–44. doi:10.4049/jimmunol.167.3.1238. PMID 11466339.

[pmid8621446-6] Gayle MA, Slack JL, Bonnert TP, Renshaw BR, Sonoda G, Taguchi T, Testa JR, Dower SK, Sims JE (Jun 1996). "Cloning of a putative ligand for the T1/ST2 receptor". J Biol Chem. 271 (10): 5784–9. doi:10.1074/jbc.271.10.5784. PMID 8621446.

[entrez-7] "Entrez Gene: TMED1 transmembrane emp24 protein transport domain containing 1".

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