Transmembrane protein 59 is a protein that in humans is encoded by the TMEM59gene.[5][6]
TMEM59 is a membrane bound protein that is localized to the Golgi apparatus.[7] The precise function of TMEM59 is not known, however it has been demonstrated that expression of TMEM59 protein inhibits Golgi glycosylation of amyloid precursor protein (APP) and blocks APP cleavage by the α- and β-amyloid precursor protein secretases and therefore inhibits formation of the beta amyloid peptide that forms amyloid plaques in Alzheimer's disease.[7] Moreover, TMEM59 has been shown to potentiate wnt signaling by promoting formation of the wnt receptor signalosomes. Transmembrane interactions between TMEM59 and the wnt receptor Frizzled were found to drive receptor multimerization that leads to improved potency and efficacy of wnt signaling.[8]
^Gerlach JP, Jordens I, Tauriello DV, van 't Land-Kuper I, Bugter JM, Noordstra I, van der Kooij J, Low TY, Pimentel-Muiños FX, Xanthakis D, Fenderico N, Rabouille C, Heck AJ, Egan DA, Maurice MM (April 2018). "TMEM59 potentiates Wnt signaling by promoting signalosome formation". Proceedings of the National Academy of Sciences of the United States of America. 115 (17): E3996–E4005. doi:10.1073/pnas.1721321115. PMC5924918. PMID29632210.
Further reading[]
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.