TMEPAI

PMEPA1
Identifiers
Aliases	PMEPA1, STAG1, TMEPAI, prostate transmembrane protein, androgen induced 1
External IDs	OMIM: 606564 MGI: 1929600 HomoloGene: 10608 GeneCards: PMEPA1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	57,711,536 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	173,276,533 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; cervix; ; prostate; ; visceral pleura; ; adipose tissue; ; putamen; ; duodenum; ; popliteal artery; ; thoracic aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	WW domain binding; R-SMAD binding; GO:0001948 protein binding;
Cellular component	integral component of membrane; Golgi membrane; endosome; plasma membrane; Golgi apparatus; early endosome membrane; endosome membrane; intracellular membrane-bounded organelle; membrane;
Biological process	androgen receptor signaling pathway; negative regulation of signal transduction; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of SMAD protein complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	56937
	65112
	ENSG00000124225
	ENSMUSG00000038400
	Q969W9
	Q9D7R2
	NM_199171; NM_001255976; NM_020182; NM_199169; NM_199170
	NM_022995
	NP_001242905; NP_064567; NP_954638; NP_954639; NP_954640
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Transmembrane prostate androgen-induced protein is a protein that in humans is encoded by the PMEPA1 gene.^[5]^[6]

Interactions[]

TMEPAI has been shown to interact with NEDD4.^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124225 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038400 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xu LL, Shanmugam N, Segawa T, Sesterhenn IA, McLeod DG, Moul JW, Srivastava S (Jun 2000). "A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate". Genomics. 66 (3): 257–63. doi:10.1006/geno.2000.6214. PMID 10873380.
^ "Entrez Gene: TMEPAI transmembrane, prostate androgen induced RNA".
^ Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.

Further reading[]

Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S (Nov 2000). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". The Biochemical Journal. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
Rae FK, Hooper JD, Nicol DL, Clements JA (Sep 2001). "Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors". Molecular Carcinogenesis. 32 (1): 44–53. doi:10.1002/mc.1063. PMID 11568975. S2CID 46602128.
Brunschwig EB, Wilson K, Mack D, Dawson D, Lawrence E, Willson JK, Lu S, Nosrati A, Rerko RM, Swinler S, Beard L, Lutterbaugh JD, Willis J, Platzer P, Markowitz S (Apr 2003). "PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer". Cancer Research. 63 (7): 1568–75. PMID 12670906.
Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.
Giannini G, Ambrosini MI, Di Marcotullio L, Cerignoli F, Zani M, MacKay AR, Screpanti I, Frati L, Gulino A (Dec 2003). "EGF- and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer". Molecular Carcinogenesis. 38 (4): 188–200. doi:10.1002/mc.10162. PMID 14639658. S2CID 22894125.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124225 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038400 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10873380-5] Xu LL, Shanmugam N, Segawa T, Sesterhenn IA, McLeod DG, Moul JW, Srivastava S (Jun 2000). "A novel androgen-regulated gene, PMEPA1, located on chromosome 20q13 exhibits high level expression in prostate". Genomics. 66 (3): 257–63. doi:10.1006/geno.2000.6214. PMID 10873380.

[entrez-6] "Entrez Gene: TMEPAI transmembrane, prostate androgen induced RNA".

[pmid12907594-7] Xu LL, Shi Y, Petrovics G, Sun C, Makarem M, Zhang W, Sesterhenn IA, McLeod DG, Sun L, Moul JW, Srivastava S (Aug 2003). "PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression". Cancer Research. 63 (15): 4299–304. PMID 12907594.

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