TMF1

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TMF1

Identifiers

TMF1, ARA160, TMF, TATA element modulatory factor 1

External IDs

OMIM: 601126 MGI: 2684999 HomoloGene: 133801 GeneCards: TMF1

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p14.1	Start	69,019,827 bp^[1]
Band	3p14.1	End	69,052,339 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 D3	Start	97,129,958 bp^[2]
Band	6\|6 D3	End	97,156,083 bp^[2]

RNA expression pattern

Top expressed in
testicle Achilles tendon corpus callosum colon stomach lung bone marrow
More reference expression data


More reference expression data

Gene ontology
Molecular function	DNA binding GO:0001104 transcription coregulator activity GO:0001948 protein binding
Cellular component	cytoplasm Golgi apparatus membrane Golgi membrane endoplasmic reticulum nucleus cytosol
Biological process	flagellated sperm motility regulation of proteasomal protein catabolic process male gonad development regulation of transcription, DNA-templated Leydig cell differentiation positive regulation of cytokine production cellular response to organic cyclic compound negative regulation of apoptotic process transcription by RNA polymerase II negative regulation of gene expression transcription, DNA-templated positive regulation of testosterone secretion defense response to bacterium acrosome assembly spermatid development luteinizing hormone secretion spermatid nucleus differentiation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


7110


232286

Ensembl


ENSG00000144747


ENSMUSG00000030059


P82094 Q6PII6


B9EKI3

RefSeq (mRNA)


NM_007114 NM_001363879


NM_001081111

RefSeq (protein)


NP_009045 NP_001350808 NP_009045.2


NP_001074580

Location (UCSC)

Chr 3: 69.02 – 69.05 Mb

Chr 6: 97.13 – 97.16 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

TATA element modulatory factor is a protein that in humans is encoded by the TMF1 gene.^[5]^[6]

Interactions[]

TMF1 has been shown to interact with FER^[7] and Androgen receptor.^[8]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144747 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030059 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Garcia JA, Ou SH, Wu F, Lusis AJ, Sparkes RS, Gaynor RB (Nov 1992). "Cloning and chromosomal mapping of a human immunodeficiency virus 1 "TATA" element modulatory factor". Proc Natl Acad Sci U S A. 89 (20): 9372–6. Bibcode:1992PNAS...89.9372G. doi:10.1073/pnas.89.20.9372. PMC 50133. PMID 1409643.
^ "Entrez Gene: TMF1 TATA element modulatory factor 1".
^ Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. 434 (3): 339–45. doi:10.1016/S0014-5793(98)01003-5. ISSN 0014-5793. PMID 9742951. S2CID 24338520.
^ Hsiao, P W; Chang C (Aug 1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. doi:10.1074/jbc.274.32.22373. ISSN 0021-9258. PMID 10428808.

Further reading[]

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Schwartz Y, Ben-Dor I, Navon A, et al. (1998). "Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases". FEBS Lett. 434 (3): 339–45. doi:10.1016/S0014-5793(98)01003-5. PMID 9742951. S2CID 24338520.
Hsiao PW, Chang C (1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. doi:10.1074/jbc.274.32.22373. PMID 10428808.
Mori K, Kato H (2002). "A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus". FEBS Lett. 520 (1–3): 127–32. doi:10.1016/S0014-5793(02)02803-X. PMID 12044884. S2CID 84784473.
Zhang Y, Fondell JD, Wang Q, et al. (2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609–18. doi:10.1038/sj.onc.1205638. PMID 12165860.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Fridmann-Sirkis Y, Siniossoglou S, Pelham HR (2004). "TMF is a golgin that binds Rab6 and influences Golgi morphology". BMC Cell Biol. 5: 18. doi:10.1186/1471-2121-5-18. PMC 419336. PMID 15128430.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Yamane J, Kubo A, Nakayama K, et al. (2007). "Functional involvement of TMF/ARA160 in Rab6-dependent retrograde membrane traffic" (PDF). Exp. Cell Res. 313 (16): 3472–85. doi:10.1016/j.yexcr.2007.07.010. hdl:2433/135781. PMID 17698061.

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