This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.[7]
Meiotic silencing[]
In mammals, surveillance mechanisms remove meiotic cells in which chromosome synapsis is defective. One such surveillance mechanism is meiotic silencing, the transcriptional silencing of genes on asynapsed chromosomes.[8] TOPBP1, a DNA damage response protein, has a crucial role in meiotic sex chromosome silencing.[8]
^Yu X, Chini CC, He M, Mer G, Chen J (Oct 2003). "The BRCT domain is a phospho-protein binding domain". Science. 302 (5645): 639–42. doi:10.1126/science.1088753. PMID14576433. S2CID29407635.
^Forma E, Wójcik-Krowiranda K, Bieńkiewicz A, Bryś M (2013) Molecular basis of gynecological oncology - TopBP1 protein as the guardian of genome integrity. Ginekol Pol 84(5):373-376
Yamane K, Chen J, Kinsella TJ (Jun 2003). "Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint". Cancer Research. 63 (12): 3049–53. PMID12810625.
Greer DA, Besley BD, Kennedy KB, Davey S (Aug 2003). "hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation". Cancer Research. 63 (16): 4829–35. PMID12941802.
Manke IA, Lowery DM, Nguyen A, Yaffe MB (Oct 2003). "BRCT repeats as phosphopeptide-binding modules involved in protein targeting". Science. 302 (5645): 636–9. doi:10.1126/science.1088877. PMID14576432. S2CID21866417.
Yu X, Chini CC, He M, Mer G, Chen J (Oct 2003). "The BRCT domain is a phospho-protein binding domain". Science. 302 (5645): 639–42. doi:10.1126/science.1088753. PMID14576433. S2CID29407635.
Reini K, Uitto L, Perera D, Moens PB, Freire R, Syväoja JE (May 2004). "TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis". Chromosoma. 112 (7): 323–30. doi:10.1007/s00412-004-0277-5. PMID15138768. S2CID30094.
Hassel S, Eichner A, Yakymovych M, Hellman U, Knaus P, Souchelnytskyi S (May 2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics. 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID15188402. S2CID6773754.