TP53INP1

TP53INP1
Identifiers
Aliases	TP53INP1, SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1, tumor protein p53 inducible nuclear protein 1
External IDs	OMIM: 606185 MGI: 1926609 HomoloGene: 11065 GeneCards: TP53INP1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	94,949,378 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	11,174,379 bp
RNA expression pattern
	Top expressed in
	ovary; ; testicle; ; prosencephalon; ; Body of pancreas; ; thymus; ; pancreas; ; blood;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antioxidant activity; GO:0001948 protein binding;
Cellular component	cytosol; PML body; autophagosome; GO:0016023 cytoplasmic vesicle; nucleus; nucleoplasm; cytoplasm;
Biological process	regulation of transcription, DNA-templated; cellular response to ethanol; positive regulation of autophagy; cellular response to methyl methanesulfonate; cellular response to UV; cellular oxidant detoxification; positive regulation of apoptotic signaling pathway; response to heat; autophagosome assembly; transcription, DNA-templated; cellular response to hydroperoxide; positive regulation of transcription, DNA-templated; autophagy; negative regulation of cell migration; regulation of autophagy; positive regulation of apoptotic process; autophagic cell death; negative regulation of cell population proliferation; apoptotic process; regulation of apoptotic process; regulation of signal transduction by p53 class mediator; positive regulation of gene expression; negative regulation of gene expression; negative regulation of fibroblast proliferation; negative regulation of myofibroblast differentiation;
	Sources:Amigo / QuickGO
Orthologs
	94241
	60599
	ENSG00000164938
	ENSMUSG00000028211
	Q96A56
	Q9QXE4
	NM_001135733; NM_033285
	NM_001199105; NM_021897
	NP_001129205; NP_150601
	NP_001186034; NP_068697
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene.^[5]^[6]^[7] In mice this protein is also called TRP53INP1 and is encoded by the Trp53inp1 gene. The protein is also referred to as SIP or "stress inducible protein"

Interactions[]

TP53INP1 has been shown to interact with HIPK2^[8] and p53.^[5]^[8]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164938 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028211 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y, Monden M, Nakamura Y (Aug 2001). "p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis". Mol Cell. 8 (1): 85–94. doi:10.1016/S1097-2765(01)00284-2. PMID 11511362.
^ Nowak J, Tomasini R, Mattei MG, Azizi Samir LA, Dagorn JC, Dusetti N, Iovanna JL, Pebusque MJ (Nov 2002). "Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization". Cytogenet Genome Res. 97 (1–2): 140E. doi:10.1159/000064049. PMID 12438758.
^ "Entrez Gene: TP53INP1 tumor protein p53 inducible nuclear protein 1".
^ ^a ^b Tomasini, Richard; Samir Amina Azizi; Carrier Alice; Isnardon Daniel; Cecchinelli Barbara; Soddu Silvia; Malissen Bernard; Dagorn Jean-Charles; Iovanna Juan L; Dusetti Nelson J (Sep 2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. United States. 278 (39): 37722–9. doi:10.1074/jbc.M301979200. ISSN 0021-9258. PMID 12851404.

Further reading[]

Tomasini R, Samir AA, Pebusque MJ, et al. (2003). "P53-dependent expression of the stress-induced protein (SIP)". Eur. J. Cell Biol. 81 (5): 294–301. doi:10.1078/0171-9335-00248. PMID 12067065.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tomasini R, Samir AA, Carrier A, et al. (2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. 278 (39): 37722–9. doi:10.1074/jbc.M301979200. PMID 12851404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hershko T, Chaussepied M, Oren M, Ginsberg D (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F". Cell Death Differ. 12 (4): 377–83. doi:10.1038/sj.cdd.4401575. PMID 15706352.
Tomasini R, Seux M, Nowak J, et al. (2006). "TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity". Oncogene. 24 (55): 8093–104. doi:10.1038/sj.onc.1208951. PMID 16044147.
Jiang PH, Motoo Y, Garcia S, et al. (2006). "Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer". World J. Gastroenterol. 12 (5): 691–6. doi:10.3748/wjg.v12.i5.691. PMC 4066117. PMID 16521180.
Ito Y, Motoo Y, Yoshida H, et al. (2007). "High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid". Pathology. 38 (6): 545–7. doi:10.1080/00313020601024094. PMID 17393983. S2CID 28578199.
Bernardo MV, Yelo E, Gimeno L, et al. (2007). "Identification of apoptosis-related PLZF target genes". Biochem. Biophys. Res. Commun. 359 (2): 317–22. doi:10.1016/j.bbrc.2007.05.085. PMID 17537403.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164938 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028211 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11511362-5] Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y, Monden M, Nakamura Y (Aug 2001). "p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis". Mol Cell. 8 (1): 85–94. doi:10.1016/S1097-2765(01)00284-2. PMID 11511362.

[pmid12438758-6] Nowak J, Tomasini R, Mattei MG, Azizi Samir LA, Dagorn JC, Dusetti N, Iovanna JL, Pebusque MJ (Nov 2002). "Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization". Cytogenet Genome Res. 97 (1–2): 140E. doi:10.1159/000064049. PMID 12438758.

[entrez-7] "Entrez Gene: TP53INP1 tumor protein p53 inducible nuclear protein 1".

[pmid12851404-8] Tomasini, Richard; Samir Amina Azizi; Carrier Alice; Isnardon Daniel; Cecchinelli Barbara; Soddu Silvia; Malissen Bernard; Dagorn Jean-Charles; Iovanna Juan L; Dusetti Nelson J (Sep 2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. United States. 278 (39): 37722–9. doi:10.1074/jbc.M301979200. ISSN 0021-9258. PMID 12851404.

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