TRIM9

TRIM9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DB8
Identifiers
Aliases	TRIM9, RNF91, SPRING, tripartite motif containing 9
External IDs	OMIM: 606555 MGI: 2137354 HomoloGene: 9045 GeneCards: TRIM9
Gene location (Human)
Chr.	Chromosome 14 (human)
End	51,096,061 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	70,394,388 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; superior frontal gyrus; ; caudate nucleus; ; nucleus accumbens; ; Brodmann area 23;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; zinc ion binding; GO:0001948 protein binding; protein homodimerization activity; transferase activity; protein domain specific binding; ubiquitin-protein transferase activity; SNARE binding;
Cellular component	cytoplasm; GO:0016023 cytoplasmic vesicle; cell junction; dendrite; cell projection; synapse; cytoskeleton; synaptic vesicle; intracellular anatomical structure; cytosol; presynaptic cytosol;
Biological process	negative regulation of calcium ion-dependent exocytosis; protein ubiquitination; negative regulation of SNARE complex assembly; synaptic vesicle exocytosis; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	114088
	94090
	ENSG00000100505
	ENSMUSG00000021071
	Q9C026
	Q8C7M3
	NM_015163; NM_052978
NM_001110202; NM_001110203; NM_001286386; NM_001286387; NM_001286388;
	NM_053167
	NP_055978; NP_443210
NP_001103672; NP_001103673; NP_001273315; NP_001273316; NP_001273317;
	NP_444397
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 9 is a protein that in humans is encoded by the TRIM9 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms.^[7]

Interactions[]

TRIM9 has been shown to interact with SNAP-25.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100505 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021071 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
^ ^a ^b Li Y, Chin LS, Weigel C, Li L (Oct 2001). "Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis". J Biol Chem. 276 (44): 40824–33. doi:10.1074/jbc.M106141200. PMID 11524423.
^ ^a ^b "Entrez Gene: TRIM9 tripartite motif-containing 9".

Further reading[]

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Ohara O, Nagase T, Ishikawa K, et al. (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins". DNA Res. 4 (1): 53–9. doi:10.1093/dnares/4.1.53. PMID 9179496.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100505 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021071 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11331580-5] Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.

[pmid11524423-6] Li Y, Chin LS, Weigel C, Li L (Oct 2001). "Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis". J Biol Chem. 276 (44): 40824–33. doi:10.1074/jbc.M106141200. PMID 11524423.

[entrez-7] "Entrez Gene: TRIM9 tripartite motif-containing 9".

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