TSPAN13

TSPAN13
Identifiers
Aliases	TSPAN13, NET-6, NET6, TM4SF13, tetraspanin 13
External IDs	OMIM: 613139 MGI: 1913359 HomoloGene: 8671 GeneCards: TSPAN13
Gene location (Human)
Chr.	Chromosome 7 (human)
End	16,784,536 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	36,092,499 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; upper lobe of lung; ; endometrium; ; parotid gland; ; prosencephalon; ; pituitary gland; ; jejunal mucosa; ; ovary; ; Brodmann area 23;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium channel regulator activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	cell surface receptor signaling pathway; regulation of calcium ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	27075
	66109
	ENSG00000106537
	ENSMUSG00000020577
	O95857
	Q9D8C2
	NM_014399
	NM_025359
	NP_055214
	NP_079635
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin-13 is a protein that in humans is encoded by the TSPAN13 gene.^[5]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.^[5]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106537 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020577 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: TSPAN13 tetraspanin 13".

Further reading[]

Böhme E, Graf H, Schultz G (1978). "Effects of sodium nitroprusside and other smooth muscle relaxants on cyclic GMP formation in smooth muscle and platelets". Advances in Cyclic Nucleotide Research. 9: 131–43. PMID 27075.
Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Serru V, Dessen P, Boucheix C, Rubinstein E (2000). "Sequence and expression of seven new tetraspans". Biochim. Biophys. Acta. 1478 (1): 159–63. doi:10.1016/S0167-4838(00)00022-4. PMID 10719184.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Huang H, Groth J, Sossey-Alaoui K, et al. (2005). "Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors". Clin. Cancer Res. 11 (12): 4357–64. doi:10.1158/1078-0432.CCR-04-2107. PMID 15958618.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Moroz MA, Serganova I, Zanzonico P, et al. (2007). "Imaging hNET reporter gene expression with 124I-MIBG". J. Nucl. Med. 48 (5): 827–36. doi:10.2967/jnumed.106.037812. PMID 17475971.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106537 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020577 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TSPAN13 tetraspanin 13".

[1]

[2]

[3]

[4]

[5]

v t Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A7
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN2 TSPAN3 TSPAN4 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN12 TSPAN13 TSPAN14 TSPAN18 TSPAN21 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders