TWSG1

TWSG1
Identifiers
Aliases	TWSG1, TSG, twisted gastrulation BMP signaling modulator 1
External IDs	OMIM: 605049 MGI: 2137520 HomoloGene: 10774 GeneCards: TWSG1
Gene location (Human)
Chr.	Chromosome 18 (human)
End	9,402,420 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	66,258,221 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; Germinal epithelium; ; tibia; ; caput epididymis; ; visceral pleura; ; endometrium; ; corpus epididymis; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GO:0001948 protein binding; transforming growth factor beta binding;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of BMP signaling pathway; multicellular organism development; mesoderm formation; cell differentiation; forebrain development; camera-type eye development; salivary gland morphogenesis; BMP signaling pathway; ossification; negative regulation of osteoblast differentiation; tissue development; positive regulation of BMP signaling pathway; negative regulation of cytokine production; transforming growth factor beta receptor signaling pathway; positive regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of CD4-positive, alpha-beta T cell activation; negative regulation of CD4-positive, alpha-beta T cell proliferation; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	57045
	65960
	ENSG00000128791
	ENSMUSG00000024098
	Q9GZX9
	Q9EP52
	NM_020648
	NM_023053
	NP_065699
	NP_075540
	Wikidata
View/Edit Human	View/Edit Mouse

Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene.^[5]^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128791 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024098 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS (Mar 2001). "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling". Nature. 410 (6827): 475–8. doi:10.1038/35068572. PMID 11260715. S2CID 4392365.
^ "Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila)".

Further reading[]

Oelgeschläger M, Larraín J, Geissert D, De Robertis EM (2000). "The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling". Nature. 405 (6788): 757–63. doi:10.1038/35015500. PMC 2292104. PMID 10866189.
Graf D, Timmons PM, Hitchins M, et al. (2001). "Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation". Mamm. Genome. 12 (7): 554–60. doi:10.1007/s0033501-0005-x. PMID 11420619. S2CID 36371559.
Graf D, Nethisinghe S, Palmer DB, et al. (2002). "The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development". J. Exp. Med. 196 (2): 163–71. doi:10.1084/jem.20020276. PMC 2193926. PMID 12119341.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zakin L, De Robertis EM (2004). "Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development". Development. 131 (2): 413–24. doi:10.1242/dev.00946. PMID 14681194.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Moreno M, Muñoz R, Aroca F, et al. (2005). "Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway". EMBO J. 24 (7): 1397–405. doi:10.1038/sj.emboj.7600615. PMC 1142540. PMID 15775969.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Tzachanis D, Li L, Lafuente EM, et al. (2007). "Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes". Blood. 109 (7): 2944–52. doi:10.1182/blood-2006-03-006510. PMC 1852213. PMID 17164348.

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128791 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024098 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11260715-5] Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS (Mar 2001). "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling". Nature. 410 (6827): 475–8. doi:10.1038/35068572. PMID 11260715. S2CID 4392365.

[entrez-6] "Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila)".

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