Tameka A. Clemons

Tameka A. Clemons is an American biochemist and Assistant Professor of Biochemistry at Meharry Medical College in Nashville, Tennessee. Clemons holds the title of Assistant Professor of Professional and Medical Education in the Division of Integrated Didactics at Meharry. Her research focuses on exploring the aberrant biochemical signalling networks in beta-cells that leads to cell death in diabetes and Alzheimer's Disease. Clemons was one of the inaugural recipients of the Alfred P. Sloan Foundation Minority Ph.D. Program Fellowship and in 2020, she was named one of the top 100 Inspiring Black Scientists in America by CellPress.

Early life and education[]

In 1998, Clemons pursued her graduate training in Biochemistry at Meharry Medical College in Nashville, Tennessee.^[1] Clemons studied in the Department of Biochemistry under the mentorship of Oksoon H. Choi.^[1] In 1999, she was one of 22 scholars to receive the inaugural Alfred P. Sloan Foundation Minority Ph.D. Program Fellowship and become a Sloan Fellow.^[2] From 2000 to 2002, Clemons successfully received the National Institutes of Health Predoctoral Individual National Research Service Award each year, as a part of the Minority Predoctoral Fellowship Program.^[3] During her PhD, Clemons explored the mechanisms by which IgE stimulation leads to calcium influx in mast cells and release of cytokines that result in allergy symptoms.^[3] She hypothesized that membrane associated sphingosine kinase (SK) signalling, leading to downstream sphingosine 1-phosphate release in the endoplasmic reticulum) is responsible for calcium mobilization in mast cells, in addition to the IP3 mediated mechanisms that had been already discovered.^[3] Clemons and her team at Meharry found that both IP3 and SK signalling are required for calcium mobilization after antigen binding to mast cells and they also found that SK signalling alone would not be sufficient to mobilize calcium.^[4] Clemons thesis was titled "Effects of sphingosine 1-phosphate in FcεRI-mediated Ca2⁺ response".^[1] Clemons completed her PhD studies in 2003.^[1]

Career and research[]

In 2004, Clemons moved to Atlanta, Georgia and founded the Alpha Kappa Alpha Incorporated Sorority Atlanta Chapter.^[5] Clemons then trained with at Western Michigan University Homer Stryker M.D. School of Medicine, where she studied the effects of hydroxyl radicals after ischemia perfusion.^[6] In 2015, Clemons became an Assistant Professor of Biochemistry in the Department of Biomedical Sciences at Western Michigan University Homer Stryker M.D. School of Medicine.^[7] She worked here for one year before becoming an assistant professor in the Department of Chemistry and Biochemistry at Spelman College in Atlanta, Georgia.^[8] While at Spelman, Clemons taught many undergraduate classes including General Chemistry, Biochemistry, Undergraduate Research in Chemistry, and Advanced Biochemistry.^[9]

In 2020, Clemons was recruited back to her alma mater, Meharry Medical College.^[10] She is an Assistant Professor of Biochemistry as well as an Assistant Professor of Professional and Medical education in the Division of Integrated Didactics at the Medical College. ^[10]

Clemons is actively involved in education and mentorship. In 2018, as a Principal Investigator at Spelman College, Clemons was a part of the NASA Technology Infusion Road Tour for Historically Black Colleges and Universities and Minority-Serving Institutions.^[11] In 2019, she spoke at the Annual Biomedical Research Conference for Minority Students (AMBRCMS) on the topic of “Post Baccalaureate Programs, Tips for Submitting a Successful Application, and Advice on Taking a Gap Year”.^[12] Clemons is also an Associate Member of the Georgia State University Center for Neuroinflammation and Cardiometabolic Diseases.^[13]

Beta-cell dysfunction[]

Clemons investigates the aberrant biochemical signalling pathways that result in beta-cell death in Type 2 Diabetes.^[14] She seeks to understand how amylin and uncoupling protein 2 (UPC2) function in both health and disease.^[15] By investigating the role of UPC2, known to suppress the impact of free radicals, on amylin function, Clemons will uncover how beta-cell death might be prevented.^[14] This work extends to the field of neurodegeneration, as Clemons also hopes to explore how UCP2 could be used to control the functions of amylin in neurons to prevent degeneration.^[16]

Awards and honors[]

• 2020 CellPress 100 Inspiring Black scientists in America^[17]
• 2019 Selected for Accomplishing Career Transitions Program through the American Society for Cell Biology^[18]
• 2018 Research Initiation Award National Science Foundation - Network of Minority Health Research Investigators^[19]
• 2000-2002 Minority Predoctoral Fellowship Program^[3]
• 1999 Inaugural Recipient of the Alfred P. Sloan Foundation Minority Ph.D. Program^[2]

Select publications[]

• Clemons TA, Toledo-Pereyra LH. Hexokinase: A Glycolytic Enzyme with an Inflammatory Ischemia and Reperfusion Connection. J Invest Surg. 2015;28(6):301-302. doi:10.3109/08941939.2015.1121674^[20]
• Lee HS, Park CS, Lee YM, Suk HY, Clemons TC, Choi OH. Antigen-induced Ca2+ mobilization in RBL-2H3 cells: role of I(1,4,5)P3 and S1P and necessity of I(1,4,5)P3 production. Cell Calcium. 2005;38(6):581-592. doi:10.1016/j.ceca.2005.08.002^[4]

References[]