Tiacumicin

Tiacumicins are a family of macrolide antibiotics derived from Dactylosporangium aurantiacum subspecies hamdenesis subspecies Nov. The tiacumicin family of antibiotics has substantial overlap with the clostomicin family.^[1]

Six 18-membered antibiotics in the tiacumicin family have been identified: tiacumicins A through F.^[1] Currently, only one of these, tiacumicin B (also lipiarmycin, clostomicin B1) is commercially available, under the generic name fidaxomicin.

References[]

^ ^a ^b Hochlowski, J. E.; Swanson, S. J.; Ranfranz, L. M.; Whittern, D. N.; Buko, A. M.; McAlpine, J. B. (1987). "Tiacumicins, a novel complex of 18-membered macrolides. II. Isolation and structure determination". The Journal of Antibiotics. 40 (5): 575–588. doi:10.7164/antibiotics.40.575. ISSN 0021-8820. PMID 3610816.

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[:0-1] Hochlowski, J. E.; Swanson, S. J.; Ranfranz, L. M.; Whittern, D. N.; Buko, A. M.; McAlpine, J. B. (1987). "Tiacumicins, a novel complex of 18-membered macrolides. II. Isolation and structure determination". The Journal of Antibiotics. 40 (5): 575–588. doi:10.7164/antibiotics.40.575. ISSN 0021-8820. PMID 3610816.

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