Tilorone

Tilorone
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth (tablets)
ATC code	J05AX19 (WHO) ;
Pharmacokinetic data
Bioavailability	60%
Protein binding	~80%
Metabolism	Nil
Elimination half-life	48 hours
Excretion	Feces (70%), urine (9%)
Identifiers
	IUPAC name 2,7-Bis(2-diethylaminoethoxy)fluoren-9-one;
CAS Number	27591-97-5 ;
PubChem CID	5475;
ChemSpider	5276 ;
UNII	O6W7VEW6KS;
KEGG	D06149 ;
ChEBI	CHEBI:147347;
ChEMBL	ChEMBL47298 ;
CompTox Dashboard (EPA)	DTXSID1045958 ;
Chemical and physical data
Formula	C25H34N2O3
Molar mass	410.558 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CC)CCOc1ccc-2c(c1)C(=O)c3c2ccc(c3)OCCN(CC)CC;
	InChI InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3 ; Key:MPMFCABZENCRHV-UHFFFAOYSA-N ;
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Tilorone (trade names Amixin, Lavomax and others) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer.^[2] It is used as an antiviral drug. It is effective against Ebola virus in mice.^[3]

Pharmacology[]

Tilorone activates the production of interferon.^[2]

References[]

^ "Registry of Medicinal Products (RLS). Tilorone: Prescribing Information" (in Russian). Retrieved 2 October 2016.
^ ^a ^b Stringfellow D, Glasgow L (1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrob Agents Chemother. 2 (2): 73–8. doi:10.1128/aac.2.2.73. PMC 444270. PMID 4670490.
^ Ekins, S.; Lingerfelt, M. A.; Comer, J. E.; Freiberg, A. N.; Mirsalis, J. C.; O'Loughlin, K.; Harutyunyan, A.; McFarlane, C.; Green, C. E.; Madrid, P. B. (2018). "Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection". Antimicrobial Agents and Chemotherapy. 62 (2). doi:10.1128/AAC.01711-17. PMC 5786809. PMID 29133569.

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[1] "Registry of Medicinal Products (RLS). Tilorone: Prescribing Information" (in Russian). Retrieved 2 October 2016.

[stringfellow-2] Stringfellow D, Glasgow L (1972). "Tilorone hydrochloride: an oral interferon-inducing agent". Antimicrob Agents Chemother. 2 (2): 73–8. doi:10.1128/aac.2.2.73. PMC 444270. PMID 4670490.

[3] Ekins, S.; Lingerfelt, M. A.; Comer, J. E.; Freiberg, A. N.; Mirsalis, J. C.; O'Loughlin, K.; Harutyunyan, A.; McFarlane, C.; Green, C. E.; Madrid, P. B. (2018). "Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection". Antimicrobial Agents and Chemotherapy. 62 (2). doi:10.1128/AAC.01711-17. PMC 5786809. PMID 29133569.

[1]

[2]

[3]

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth (tablets)
ATC code	J05AX19 (WHO)
Pharmacokinetic data
Bioavailability	60%
Protein binding	~80%
Metabolism	Nil
Elimination half-life	48 hours
Excretion	Feces (70%), urine (9%)^[1]
Identifiers
IUPAC name 2,7-Bis(2-diethylaminoethoxy)fluoren-9-one
CAS Number	27591-97-5^Y
PubChem CID	5475
ChemSpider	5276^N
UNII	O6W7VEW6KS
KEGG	D06149^N
ChEBI	CHEBI:147347
ChEMBL	ChEMBL47298^N
CompTox Dashboard (EPA)	DTXSID1045958
Chemical and physical data
Formula	C₂₅H₃₄N₂O₃
Molar mass	410.558 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN(CC)CCOc1ccc-2c(c1)C(=O)c3c2ccc(c3)OCCN(CC)CC
InChI InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3^N Key:MPMFCABZENCRHV-UHFFFAOYSA-N^N
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