Tombus virus defective interfering (DI) RNA region 3

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Tombus virus defective interfering (DI) RNA region 3
RF00215.jpg
Predicted secondary structure and sequence conservation of Tombus_3_III
Identifiers
SymbolTombus_3_III
RfamRF00215
Other data
RNA typeCis-reg
Domain(s)Viruses
SOSO:0000233
PDB structuresPDBe

Tombus virus defective interfering (DI) RNA region 3 is an important cis-regulatory region identified in the 3' UTR of Tombusvirus defective interfering particles (DI).[1]

Defective interfering RNAs are small sub-viral replicons which are non-coding deletion mutants of the virus that maintain cis-acting RNA elements necessary for replication of the host virus.[1] This conserved region of the 3'UTR has been found to enhance DI RNA accumulation by approximately 10-fold as well as mediating viral replication.[1]

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References[]

  1. ^ a b c Ray D, White KA (2003). "An internally located RNA hairpin enhances replication of Tomato bushy stunt virus RNAs". J. Virol. 77 (1): 245–257. doi:10.1128/JVI.77.1.245-257.2003. PMC 140596. PMID 12477830.

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