UACA

UACA
Identifiers
Aliases	UACA, NUCLING, uveal autoantigen with coiled-coil domains and ankyrin repeats
External IDs	OMIM: 612516 MGI: 1919815 HomoloGene: 74297 GeneCards: UACA
Gene location (Human)
Chr.	Chromosome 15 (human)
End	70,763,558 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	60,787,652 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; visceral pleura; ; sural nerve; ; quadriceps femoris muscle; ; inferior ganglion of vagus nerve; ; cerebellum; ; deltoid muscle; ; tibial nerve; ; cardia; ; occipital lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:0001948 protein binding; molecular function;
Cellular component	extracellular region; extracellular exosome; cytoskeleton; nucleus; cytoplasm; cytosol;
Biological process	apoptotic signaling pathway; regulation of NIK/NF-kappaB signaling; biological process;
	Sources:Amigo / QuickGO
Orthologs
	55075
	72565
	ENSG00000137831
	ENSMUSG00000034485
	Q9BZF9
	Q8CGB3
	NM_001008224; NM_018003
	NM_028283; NM_001357407; NM_001357408
	NP_001008225; NP_060473
	NP_082559; NP_001344336; NP_001344337
	Wikidata
View/Edit Human	View/Edit Mouse

Uveal autoantigen with coiled-coil domains and ankyrin repeats is a protein that in humans is encoded by the UACA gene.^[5]^[6]^[7]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137831 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034485 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamada K, Senju S, Nakatsura T, Murata Y, Ishihara M, Nakamura S, Ohno S, Negi A, Nishimura Y (Feb 2001). "Identification of a novel autoantigen UACA in patients with panuveitis". Biochem. Biophys. Res. Commun. 280 (4): 1169–76. doi:10.1006/bbrc.2001.4189. PMID 11162650.
^ Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
^ "Entrez Gene: UACA uveal autoantigen with coiled-coil domains and ankyrin repeats".

Further reading[]

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ohkura T, Taniguchi S, Yamada K, et al. (2004). "Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease". Biochem. Biophys. Res. Commun. 321 (2): 432–40. doi:10.1016/j.bbrc.2004.06.162. PMID 15358194.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137831 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034485 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11162650-5] Yamada K, Senju S, Nakatsura T, Murata Y, Ishihara M, Nakamura S, Ohno S, Negi A, Nishimura Y (Feb 2001). "Identification of a novel autoantigen UACA in patients with panuveitis". Biochem. Biophys. Res. Commun. 280 (4): 1169–76. doi:10.1006/bbrc.2001.4189. PMID 11162650.

[pmid10997877-6] Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.

[entrez-7] "Entrez Gene: UACA uveal autoantigen with coiled-coil domains and ankyrin repeats".

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