UBE2D1

UBE2D1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C4P, 2YHO, 3OJ4, 3PTF, 4AP4, 4QPL, 5FER
Identifiers
Aliases	UBE2D1, E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A, ubiquitin conjugating enzyme E2 D1
External IDs	OMIM: 602961 MGI: 2384911 HomoloGene: 20714 GeneCards: UBE2D1
EC number	2.3.2.24
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q21.1 Start 58,334,979 bp[1] End 58,370,751 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B5.3 Start 71,090,810 bp[2] End 71,121,092 bp[2]
RNA expression pattern Bgee Top expressed in biceps brachii vastus lateralis muscle quadriceps femoris muscle myocardium right ventricle blood deltoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding transferase activity ubiquitin conjugating enzyme activity ATP binding GO:0001948 protein binding ubiquitin-protein transferase activity ubiquitin protein ligase binding Cellular component cytoplasm nucleoplasm cytosol ubiquitin ligase complex protein-containing complex Biological process protein K48-linked ubiquitination BMP signaling pathway protein polyubiquitination negative regulation of transcription by RNA polymerase II anaphase-promoting complex-dependent catabolic process positive regulation of protein ubiquitination ubiquitin-dependent protein catabolic process protein ubiquitination protein deubiquitination positive regulation of protein polyubiquitination protein targeting to peroxisome regulation of mitotic cell cycle phase transition MyD88-independent toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7321	216080
Ensembl	ENSG00000072401	ENSMUSG00000019927
UniProt	P51668	P61080
RefSeq (mRNA)	NM_003338 NM_001204880	NM_145420
RefSeq (protein)	NP_001191809 NP_003329	NP_663395
Location (UCSC)	Chr 10: 58.33 – 58.37 Mb	Chr 10: 71.09 – 71.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.^[5][6][7]

Function[]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.^[7]

Interactions[]

UBE2D1 has been shown to interact with:

• BARD1,^{[8][9][10][11][12][13][14][15]}
• BRCA1,^{[8][9][10][11][12][13][14][15][16][17]} and
• UBE3A.^[18][19]

References[]

Further reading[]