UHRF2
UHRF2 | |||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||
Aliases | UHRF2, NIRF, RNF107, URF2, TDRD23, ubiquitin like with PHD and ring finger domains 2 | ||||||||||||||||||||||||
External IDs | OMIM: 615211 MGI: 1923718 HomoloGene: 17001 GeneCards: UHRF2 | ||||||||||||||||||||||||
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Species | Human | Mouse | |||||||||||||||||||||||
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Location (UCSC) | Chr 9: 6.41 – 6.51 Mb | Chr 19: 30.01 – 30.07 Mb | |||||||||||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||||||||||
Wikidata | |||||||||||||||||||||||||
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E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.[5][6]
This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.[6]
References[]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000147854 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024817 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation". Biochem Biophys Res Commun. 296 (3): 530–6. doi:10.1016/S0006-291X(02)00890-2. PMID 12176013.
- ^ a b "Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2".
Further reading[]
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain". Oncogene. 23 (46): 7601–10. doi:10.1038/sj.onc.1208053. PMID 15361834.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Li Y, Mori T, Hata H, et al. (2004). "NIRF induces G1 arrest and associates with Cdk2". Biochem. Biophys. Res. Commun. 319 (2): 464–8. doi:10.1016/j.bbrc.2004.04.190. PMID 15178429.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Mori T, Li Y, Hata H, Kochi H (2004). "NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein". FEBS Lett. 557 (1–3): 209–14. doi:10.1016/S0014-5793(03)01495-9. PMID 14741369. S2CID 10006213.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Categories:
- Genes on human chromosome 9
- Human chromosome 9 gene stubs