WDR1

WDR1
Identifiers
Aliases	WDR1, AIP1, HEL-S-52, NORI-1, WD repeat domain 1, PFITS
External IDs	OMIM: 604734 MGI: 1337100 HomoloGene: 6628 GeneCards: WDR1
Gene location (Human)
Chr.	Chromosome 4 (human)
End	10,116,949 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	38,720,564 bp
RNA expression pattern
	Top expressed in
	testicle; ; popliteal artery; ; parotid gland; ; smooth muscle tissue; ; thoracic aorta; ; left coronary artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin binding; actin filament binding;
Cellular component	extracellular region; myelin sheath; podosome; cell junction; cell projection; extracellular exosome; cytoskeleton; actin filament; cell-cell junction; cytoplasm; cytosol; cortical actin cytoskeleton; plasma membrane;
Biological process	platelet degranulation; sensory perception of sound; actin cytoskeleton organization; regulation of ventricular cardiac muscle cell membrane repolarization; regulation of oligodendrocyte differentiation; maintenance of epithelial cell apical/basal polarity; apical junction assembly; regulation of actin filament depolymerization; neutrophil mediated immunity; regulation of cell shape; actin filament fragmentation; platelet formation; positive regulation of actin filament depolymerization; cortical cytoskeleton organization; locomotion; establishment of planar polarity of follicular epithelium; sarcomere organization; neutrophil migration; actin filament depolymerization;
	Sources:Amigo / QuickGO
Orthologs
	9948
	22388
	ENSG00000071127
	ENSMUSG00000005103
	O75083
	O88342
	NM_005112; NM_017491
	NM_011715
	NP_005103; NP_059830
	NP_035845
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.^[5]^[6]

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.^[6]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000071127 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005103 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Adler HJ, Winnicki RS, Gong TW, Lomax MI (May 1999). "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein". Genomics. 56 (1): 59–69. doi:10.1006/geno.1998.5672. PMID 10036186.
^ ^a ^b "Entrez Gene: WDR1 WD repeat domain 1".

Further reading[]

Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Rodal AA, Tetreault JW, Lappalainen P, et al. (1999). "Aip1p interacts with cofilin to disassemble actin filaments". J. Cell Biol. 145 (6): 1251–64. doi:10.1083/jcb.145.6.1251. PMC 2133144. PMID 10366597.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Fujibuchi T, Abe Y, Takeuchi T, et al. (2005). "AIP1/WDR1 supports mitotic cell rounding". Biochem. Biophys. Res. Commun. 327 (1): 268–75. doi:10.1016/j.bbrc.2004.11.156. PMID 15629458.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000071127 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005103 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10036186-5] Adler HJ, Winnicki RS, Gong TW, Lomax MI (May 1999). "A gene upregulated in the acoustically damaged chick basilar papilla encodes a novel WD40 repeat protein". Genomics. 56 (1): 59–69. doi:10.1006/geno.1998.5672. PMID 10036186.

[entrez-6] "Entrez Gene: WDR1 WD repeat domain 1".

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