WDR3

WDR3
Identifiers
Aliases	WDR3, DIP2, UTP12, WD repeat domain 3
External IDs	OMIM: 604737 MGI: 2443143 HomoloGene: 4937 GeneCards: WDR3
Gene location (Human)
Chr.	Chromosome 1 (human)
End	117,966,543 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	100,069,723 bp
RNA expression pattern
	Top expressed in
	ovary; ; testicle; ; prosencephalon; ; vagina; ; synovial membrane; ; endometrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	snoRNA binding; RNA binding;
Cellular component	Pwp2p-containing subcomplex of 90S preribosome; small-subunit processome; nuclear membrane; nucleolus; nucleoplasm; nucleus;
Biological process	rRNA processing; maturation of SSU-rRNA;
	Sources:Amigo / QuickGO
Orthologs
	10885
	269470
	ENSG00000065183
	ENSMUSG00000033285
	Q9UNX4
	Q8BHB4
	NM_006784
	NM_175552; NM_001355657
	NP_006775
	NP_780761; NP_001342586
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat-containing protein 3 is a protein that in humans is encoded by the WDR3 gene.^[5]^[6]

This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.^[6]

Model organisms[]

*Wdr3* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Abnormal
Recessive lethal study	Abnormal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Brain histopathology	Normal
Salmonella infection	Normal^[7]
Citrobacter infection	Normal^[8]
All tests and analysis from^[9]^[10]

Model organisms have been used in the study of WDR3 function. A conditional knockout mouse line, called Wdr3^{tm1a(KOMP)Wtsi}^[11]^[12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[13]^[14]^[15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[9]^[16] Twenty four tests were carried out on mutant mice and two significant abnormalities were observed.^[9] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.^[9]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065183 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033285 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Claudio JO, Liew CC, Ma J, Heng HH, Stewart AK, Hawley RG (Aug 1999). "Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13". Genomics. 59 (1): 85–9. doi:10.1006/geno.1999.5858. PMID 10395803.
^ ^a ^b "Entrez Gene: WDR3 WD repeat domain 3".
^ "Salmonella infection data for Wdr3". Wellcome Trust Sanger Institute.
^ "Citrobacter infection data for Wdr3". Wellcome Trust Sanger Institute.
^ ^a ^b ^c ^d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
^ "International Knockout Mouse Consortium".
^ "Mouse Genome Informatics".
^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
^ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading[]

Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Claudio JO, Liew CC, Dempsey AA, et al. (1999). "Identification of sequence-tagged transcripts differentially expressed within the human hematopoietic hierarchy". Genomics. 50 (1): 44–52. doi:10.1006/geno.1998.5308. PMID 9628821.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065183 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033285 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10395803-5] Claudio JO, Liew CC, Ma J, Heng HH, Stewart AK, Hawley RG (Aug 1999). "Cloning and expression analysis of a novel WD repeat gene, WDR3, mapping to 1p12-p13". Genomics. 59 (1): 85–9. doi:10.1006/geno.1999.5858. PMID 10395803.

[entrez-6] "Entrez Gene: WDR3 WD repeat domain 3".

[''Salmonella''_infection-7] "Salmonella infection data for Wdr3". Wellcome Trust Sanger Institute.

[''Citrobacter''_infection-8] "Citrobacter infection data for Wdr3". Wellcome Trust Sanger Institute.

[mgp_reference-9] Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.

[10] Mouse Resources Portal, Wellcome Trust Sanger Institute.

[allele_ref-11] "International Knockout Mouse Consortium".

[mgi_allele_ref-12] "Mouse Genome Informatics".

[pmid21677750-13] Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.

[mouse_library-14] Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.

[mouse_for_all_reasons-15] Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.

[pmid21722353-16] van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

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