WWC1

WWC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2Z0U
Identifiers
Aliases	WWC1, HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168, WW and C2 domain containing 1
External IDs	OMIM: 610533 MGI: 2388637 HomoloGene: 69180 GeneCards: WWC1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	168,472,303 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	35,871,354 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; salivary gland; ; vagina; ; kidney; ; renal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:0001105 transcription coactivator activity; kinase binding; GO:0001948 protein binding; GO:0032947 molecular adaptor activity;
Cellular component	cytoplasm; cytosol; cell projection; membrane; plasma membrane; ruffle membrane; perinuclear region of cytoplasm; nucleus; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; hippo signaling; transcription, DNA-templated; negative regulation of hippo signaling; establishment of cell polarity; regulation of hippo signaling; negative regulation of organ growth; cell migration; positive regulation of MAPK cascade; regulation of intracellular transport; positive regulation of transcription of Notch receptor target;
	Sources:Amigo / QuickGO
Orthologs
	23286
	211652
	ENSG00000113645
	ENSMUSG00000018849
	Q8IX03
	Q5SXA9
	NM_001161661; NM_001161662; NM_015238
	NM_170779
	NP_001155133; NP_001155134; NP_056053
	NP_740749
	Wikidata
View/Edit Human	View/Edit Mouse

Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1 gene.^[5]^[6]^[7]

Research on human memory[]

A single nucleotide polymorphism (rs17070145) ^[8] in the gene has been associated with human memory performance in one 2006 study.^[9] While no significant support for KIBRA's association with memory was found in a 2008 study with 584 subjects,^[10] the original 2006 study was replicated in a smaller sample of an elderly population in 2008.^[11] A subsequent study in 2009 in two large UK samples indicated that KIBRA is specifically associated with forgetting of non-semantic material.^[12]

Studies have also begun to investigate the role of KIBRA in Alzheimer's disease.^[13]

Interactions[]

KIBRA has at least 10 interaction partners, including synaptopodin, PKCζ and Dendrin, most of which modify synaptic plasticity. For instance, Dendrin is a post-synaptic protein with expression regulated by sleep deprivation.^[14] KIBRA has been shown to interact with Protein kinase Mζ.^[15]

References[]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113645 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018849 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, p Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ Kremerskothen J, Plaas C, Büther K, Finger I, Veltel S, Matanis T, Liedtke T, Barnekow A (Jan 2003). "Characterization of KIBRA, a novel WW domain-containing protein". Biochem Biophys Res Commun. 300 (4): 862–7. doi:10.1016/S0006-291X(02)02945-5. PMID 12559952.
^ "Entrez Gene: WWC1 WW and C2 domain containing 1".
^ "dbSNP: rs17070145".
^ Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A, Coluccia D, Hänggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ (October 2006). "Common Kibra alleles are associated with human memory performance". Science. 314 (5798): 475–8. Bibcode:2006Sci...314..475P. doi:10.1126/science.1129837. PMID 17053149.
^ Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, Gumbs CE, Giegling I, Möller HJ, Francks C, Muglia P, Roses A, Gibson G, Weale ME, Rujescu D, Goldstein DB (July 2008). "Failure to replicate effect of Kibra on human memory in two large cohorts of European origin". American Journal of Medical Genetics. 147B (5): 667–8. doi:10.1002/ajmg.b.30658. hdl:11858/00-001M-0000-0012-C950-9. PMID 18205171.
^ Schaper K, Kolsch H, Popp J, Wagner M, Jessen F (July 2008). "KIBRA gene variants are associated with episodic memory in healthy elderly". Neurobiol. Aging. 29 (7): 1123–5. doi:10.1016/j.neurobiolaging.2007.02.001. PMID 17353070.
^ Bates TC, Price JF, Harris SE, Marioni RE, Fowkes FG, Stewart MC, Murray GD, Whalley LJ, Starr JM, Deary IJ (July 2009). "Association of KIBRA and memory". Neurosci. Lett. 458 (3): 140–3. doi:10.1016/j.neulet.2009.04.050. PMID 19397951.
^ Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ (June 2010). "Evidence for an association between KIBRA and late-onset Alzheimer's disease". Neurobiol. Aging. 31 (6): 901–9. doi:10.1016/j.neurobiolaging.2008.07.014. PMC 2913703. PMID 18789830. Lay summary – ScienceDaily. {{cite journal}}: Cite uses deprecated parameter |lay-url= (help)
^ Schneider A, Huentelman MJ, Kremerskothen J, Duning K, Spoelgen R, Nikolich K (2010). "KIBRA: A New Gateway to Learning and Memory?". Frontiers in Aging Neuroscience. 2: 4. doi:10.3389/neuro.24.004.2010. PMC 2874402. PMID 20552044.
^ Büther K, Plaas C, Barnekow A, Kremerskothen J (May 2004). "KIBRA is a novel substrate for protein kinase Czeta". Biochem. Biophys. Res. Commun. 317 (3): 703–7. doi:10.1016/j.bbrc.2004.03.107. PMID 15081397.

External links[]

Division of Cognitive Neuroscience, University of Basel, Switzerland

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by .

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113645 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018849 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, p Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[pmid12559952-6] Kremerskothen J, Plaas C, Büther K, Finger I, Veltel S, Matanis T, Liedtke T, Barnekow A (Jan 2003). "Characterization of KIBRA, a novel WW domain-containing protein". Biochem Biophys Res Commun. 300 (4): 862–7. doi:10.1016/S0006-291X(02)02945-5. PMID 12559952.

[entrez-7] "Entrez Gene: WWC1 WW and C2 domain containing 1".

[8] "dbSNP: rs17070145".

[pmid17053149-9] Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A, Coluccia D, Hänggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ (October 2006). "Common Kibra alleles are associated with human memory performance". Science. 314 (5798): 475–8. Bibcode:2006Sci...314..475P. doi:10.1126/science.1129837. PMID 17053149.

[pmid18205171-10] Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, Gumbs CE, Giegling I, Möller HJ, Francks C, Muglia P, Roses A, Gibson G, Weale ME, Rujescu D, Goldstein DB (July 2008). "Failure to replicate effect of Kibra on human memory in two large cohorts of European origin". American Journal of Medical Genetics. 147B (5): 667–8. doi:10.1002/ajmg.b.30658. hdl:11858/00-001M-0000-0012-C950-9. PMID 18205171.

[pmid17353070-11] Schaper K, Kolsch H, Popp J, Wagner M, Jessen F (July 2008). "KIBRA gene variants are associated with episodic memory in healthy elderly". Neurobiol. Aging. 29 (7): 1123–5. doi:10.1016/j.neurobiolaging.2007.02.001. PMID 17353070.

[pmid19397951-12] Bates TC, Price JF, Harris SE, Marioni RE, Fowkes FG, Stewart MC, Murray GD, Whalley LJ, Starr JM, Deary IJ (July 2009). "Association of KIBRA and memory". Neurosci. Lett. 458 (3): 140–3. doi:10.1016/j.neulet.2009.04.050. PMID 19397951.

[pmid18789830-13] Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ (June 2010). "Evidence for an association between KIBRA and late-onset Alzheimer's disease". Neurobiol. Aging. 31 (6): 901–9. doi:10.1016/j.neurobiolaging.2008.07.014. PMC 2913703. PMID 18789830. Lay summary – ScienceDaily. {{cite journal}}: Cite uses deprecated parameter |lay-url= (help)

[pmid20552044-14] Schneider A, Huentelman MJ, Kremerskothen J, Duning K, Spoelgen R, Nikolich K (2010). "KIBRA: A New Gateway to Learning and Memory?". Frontiers in Aging Neuroscience. 2: 4. doi:10.3389/neuro.24.004.2010. PMC 2874402. PMID 20552044.

[pmid15081397-15] Büther K, Plaas C, Barnekow A, Kremerskothen J (May 2004). "KIBRA is a novel substrate for protein kinase Czeta". Biochem. Biophys. Res. Commun. 317 (3): 703–7. doi:10.1016/j.bbrc.2004.03.107. PMID 15081397.

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WWC1

Contents

Research on human memory[]

Interactions[]

References[]

Further reading[]

External links[]