Zinc finger protein 426

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ZNF426
Identifiers
Aliases	ZNF426, K-RBP, zinc finger protein 426
External IDs	MGI: 1920248 HomoloGene: 23435 GeneCards: ZNF426
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 9,523,223 bp[1] End 9,538,645 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A3|9 7.55 cM Start 20,468,549 bp[2] End 20,492,746 bp[2]
Gene ontology Molecular function • DNA binding • GO:0001948 protein binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • intracellular anatomical structure • nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79088	235028
Ensembl	ENSG00000130818	ENSMUSG00000059475
UniProt	Q9BUY5	Q8R1D1
RefSeq (mRNA)	NM_001300883 NM_024106 NM_001318055 NM_001318056	NM_001110309 NM_146221 NM_001310742
RefSeq (protein)	NP_001287812 NP_001304984 NP_001304985 NP_077011	NP_001103779 NP_001297671 NP_666333
Location (UCSC)	Chr 19: 9.52 – 9.54 Mb	Chr 9: 20.47 – 20.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 426 is a protein that in humans is encoded by the ZNF426 gene. ^[5]

Function[]

Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene.

References[]

Further reading[]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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