A-372159

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A-372159
A-372159.svg
Identifiers
IUPAC name
  • (8aS,12aR)-2-(4-isopropoxy-2-(trifluoromethyl)phenyl)-6,7,8a,9,10,11,12,12a-octahydro-5H-[1,4]oxazepino[2,3,4-hi]pyrido[4,3-b]indole
CAS Number
ChemSpider
Chemical and physical data
FormulaC24H27F3N2O2
Molar mass432.487 g·mol−1
3D model (JSmol)
SMILES
  • FC(F)(C1=C(C2=CC3=C4C(OCCCN4[C@@]5([H])CCNC[C@@]35[H])=C2)C=CC(OC(C)C)=C1)F
InChI
  • InChI=1S/C24H27F3N2O2/c1-14(2)31-16-4-5-17(20(12-16)24(25,26)27)15-10-18-19-13-28-7-6-21(19)29-8-3-9-30-22(11-15)23(18)29/h4-5,10-12,14,19,21,28H,3,6-9,13H2,1-2H3/t19-,21-/m0/s1 checkY
  • Key:LADKOBQJOCFCQU-FPOVZHCZSA-N checkY
  

A-372159 is a drug which acts as a potent and selective partial agonist for the 5HT2C receptor, with more than 100x selectivity over the closely related 5-HT2B receptor and a Ki of 3nM. It has been found to produce anorectic effects in animal studies and produced significant weight loss in rats with no development of tolerance or serious side effects.[1]

References[]

  1. ^ Childers WE, Robichaud AJ (January 2005). "Recent advances in selective serotonergic agents". Annual Reports in Medicinal Chemistry. 40: 17–33. doi:10.1016/S0065-7743(05)40002-0. ISBN 978-0-12-040540-4.


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