AAZ-A-154

AAZ-A-154
Identifiers
	IUPAC name (2R)-1-(5-methoxy-1H-indol-1-yl)-N,N-dimethylpropan-2-amine;
PubChem CID	154694212;
Chemical and physical data
Formula	C14H20N2O
Molar mass	232.327 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)[C@H](C)Cn1ccc2cc(ccc21)OC;
	InChI InChI=1S/C14H20N2O/c1-11(15(2)3)10-16-8-7-12-9-13(17-4)5-6-14(12)16/h5-9,11H,10H2,1-4H3/t11-/m1/s1; Key:KHEUWLQKCXGVEL-LLVKDONJSA-N;

AAZ-A-154 is an isotryptamine derivative which acts as a 5-HT_2A receptor agonist. Animal studies suggest that it produces antidepressant effects without the psychedelic action typical of drugs from this class.^[1]^[2] In tests, AAZ-A-154 had antidepressant effects in mice without causing the head-twitch response linked to hallucinogenic effects.^[3]

References[]

^ Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, Azinfar A, Oh WC, Wetsel WC, Olson DE, Tian L (May 2021). "Psychedelic-inspired drug discovery using an engineered biosensor". Cell. 184 (10): 2779–2792.e18. doi:10.1016/j.cell.2021.03.043. PMID 33915107.
^ WO 2020176597, Olson DE, Dunlap L, Wagner FF, "N-substituted indoles and other heterocycles for treating brain disorders", published 3 September 2020, assigned to The Regents of the University of California
^ Cross, Ryan (2021-09-27). "Delix raises $70 million to synthesize psychedelic-inspired drugs". cen.acs.org. Archived from the original on 2021-09-27. Retrieved 2022-01-14.

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[pmid33915107-1] Dong C, Ly C, Dunlap LE, Vargas MV, Sun J, Hwang IW, Azinfar A, Oh WC, Wetsel WC, Olson DE, Tian L (May 2021). "Psychedelic-inspired drug discovery using an engineered biosensor". Cell. 184 (10): 2779–2792.e18. doi:10.1016/j.cell.2021.03.043. PMID 33915107.

[2] WO 2020176597, Olson DE, Dunlap L, Wagner FF, "N-substituted indoles and other heterocycles for treating brain disorders", published 3 September 2020, assigned to The Regents of the University of California

[3] Cross, Ryan (2021-09-27). "Delix raises $70 million to synthesize psychedelic-inspired drugs". cen.acs.org. Archived from the original on 2021-09-27. Retrieved 2022-01-14.

[1]

[2]

[3]

Identifiers

IUPAC name (2R)-1-(5-methoxy-1H-indol-1-yl)-N,N-dimethylpropan-2-amine
PubChem CID	154694212
Chemical and physical data
Formula	C₁₄H₂₀N₂O
Molar mass	232.327 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)[C@H](C)Cn1ccc2cc(ccc21)OC
InChI InChI=1S/C14H20N2O/c1-11(15(2)3)10-16-8-7-12-9-13(17-4)5-6-14(12)16/h5-9,11H,10H2,1-4H3/t11-/m1/s1 Key:KHEUWLQKCXGVEL-LLVKDONJSA-N

AAZ-A-154

See also[]

References[]