ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4gene.[5][6]
ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus.[7] MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.[8]
MRP4/ABCC4 expression is dysregulated in several cancers [9][10][11] and is also upregulated in peritoneal endometriosis.[12]
^Holla VR, Backlund MG, Yang P,Newman RA, DuBois RN. Regulation of prostaglandin transporters in colorectalneoplasia. Cancer Prev Res (Phila). 2008;1(2) 93-9.
^Gori I, Rodriguez Y, Pellegrini C, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, Canny GO (2013). "Augmented epithelial multidrug resistance-associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A(4)". Fertil Steril. 99 (7): 1965–1973.e2. doi:10.1016/j.fertnstert.2013.01.146. PMID23472950.
Ban H, Andoh A, Imaeda H, Kobori A, Bamba S, Tsujikawa T, Sasaki M, Saito Y, Fujiyama Y (October 2010). "The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease". Journal of Gastroenterology. 45 (10): 1014–21. doi:10.1007/s00535-010-0248-y. PMID20393862. S2CID586429.
Ming X, Thakker DR (February 2010). "Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil". Biochemical Pharmacology. 79 (3): 455–62. doi:10.1016/j.bcp.2009.08.029. PMID19735648.
Clemente MI, Alvarez S, Serramía MJ, Turriziani O, Genebat M, Leal M, Fresno M, Muñoz-Fernández MA (2009). "Non-steroidal anti-inflammatory drugs increase the antiretroviral activity of nucleoside reverse transcriptase inhibitors in HIV type-1-infected T-lymphocytes: role of multidrug resistance protein 4". Antiviral Therapy. 14 (8): 1101–11. doi:10.3851/IMP1468. PMID20032540.
Radilova H, Libra A, Holasova S, Safarova M, Viskova A, Kunc F, Buncek M (October 2009). "COX-1 is coupled with mPGES-1 and ABCC4 in human cervix cancer cells". Molecular and Cellular Biochemistry. 330 (1–2): 131–40. doi:10.1007/s11010-009-0126-1. PMID19399588. S2CID25586752.
Yuasa I, Umetsu K, Matsusue A, Nishimukai H, Harihara S, Fukumori Y, Saitou N, Jin F, Chattopadhyay PK, Henke L, Henke J (July 2010). "A Japanese-specific allele in the GALNT11 gene". Legal Medicine. 12 (4): 208–11. doi:10.1016/j.legalmed.2010.04.001. PMID20547088.