Adipokine
The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are cytokines (cell signaling proteins) secreted by adipose tissue. The first adipokine to be discovered was leptin in 1994.[1] Since that time, hundreds of adipokines have been discovered.[2]
Members include:
- Leptin
- Adiponectin
- Apelin[3]
- chemerin[4]
- interleukin-6 (IL-6)[5]
- monocyte chemotactic protein-1 (MCP-1)[6]
- plasminogen activator inhibitor-1 (PAI-1)
- retinol binding protein 4 (RBP4)
- tumor necrosis factor-alpha (TNFα)[7]
- visfatin
- omentin
- (SERPINA12)
- progranulin
- CTRP-4
In addition, interleukin 8 (IL-8), interleukin 10 (IL-10), interferon gamma (IFN-γ) and inducible protein 10 (IP-10 or CXCL10) have been shown to be associated with excessive body weight.[8]
Notes[]
- ^ Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O (2011). "Adipokines: BioFactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity". BioFactors. 37 (6): 413–420. doi:10.1002/biof.185. PMID 22038756.
- ^ Lehr S, Hartwig S, Sell H (2012). "Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders". Proteomics: Clinical Applications. 6 (1–2): 91–101. doi:10.1002/prca.201100052. PMID 22213627.
- ^ Guo L, Li Q, Wang W, Yu P, Pan H, Li P, Sun Y, Zhang J. Endocr Res. 2009;34(4):142-54.
- ^ MacDougald1, Ormond A. and Burant, Charles F. (September 2007) "The Rapidly Expanding Family of Adipokines" Cell Metabolism 6: pp. 159-161
- ^ Monzillo, Lais U. (2003) "Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance" Obesity Research 11(9): pp. 1048-1054
- ^ Christiansen T., Richelsen B., and Bruun J.M. (2005) "Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects" International Journal of Obesity 29: pp. 146–150
- ^ Sethi JK, Hotamisligil GS (2021). "Metabolic Messengers: tumour necrosis factor". Nature Metabolism. 3 (10): 1302–1312. doi:10.1038/s42255-021-00470-z. PMID 34650277.
- ^ Sharabiani, MT; Vermeulen R; Scoccianti C; Hosnijeh FS; Minelli L; Sacerdote C; Palli D; Krogh V; Tumino R; Chiodini P; Panico S; Vineis P. (May 2011). "Immunologic profile of excessive body weight". Biomarkers. 16 (3): 243–51. doi:10.3109/1354750X.2010.547948. PMID 21506696.
External links[]
- Adipokines at the US National Library of Medicine Medical Subject Headings (MeSH)
Categories:
- Cytokines