State Route 110 (SR 110) is a 32.257-mile-long (51.913 km) state highway in the central part of the U.S. state of Alabama. The western terminus of the highway is at an intersection with SR 126 within sight of the Interstate 85 (I-85) and U.S. Route 80 (US 80) interchange in the eastern part of Montgomery. The eastern terminus of the highway is at an intersection with US 82 west of Union Springs, Alabama.
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SR 110 begins at an intersection with SR 126 near the interchange with I-85/US 80 approximately 11 miles (18 km) east of downtown Montgomery. From its beginning, it heads southeast from Montgomery County into rural areas of that county. It has an incomplete interchange with SR 108 (which is the placeholder for the future re-routing of I-85 around Montgomery. It then has an intersection with the southern terminus of SR 293. It then enters Bullock County. Along its two-lane roadway, the highway travels through a number of small, unincorporated communities and farmland as it heads towards Union Springs. SR 110 reaches its eastern terminus approximately 2 miles (3.2 km) west of Union Springs, where motorists must then take US 82 (internally designated as SR 6).